Dapagliflozin Impurity 152 CAS 2459303-35-4
| CAS No. | 2459303-35-4 |
| Molecular Formula | C21H25ClO6 |
| Molecular Weight | 408.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dapagliflozin Impurity 152 (C21H25ClO6) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Dapagliflozin Impurity 152 (CAS 2459303-35-4) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25ClO6 and a molecular weight of 408.87 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dapagliflozin Impurity 152 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H25ClO6 |
| Molecular Weight | 408.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Furanose Isomer (CAS 1469910-70-0)
- Dapagliflozin Impurity N9 (CAS 2452300-81-9)
- Dapagliflozin (CAS 461432-26-8)
- Dapagliflozin Impurity 1 (CAS 1373321-04-0)
- Dapagliflozin Impurity 126 (CAS CATO-C4X-1138126)
- Dapagliflozin Impurity 144 (CAS 1408245-02-2)
- Dapagliflozin Impurity 15 (CAS CATO-C4X-113815)
- Dapagliflozin Impurity 2 (CAS 2271248-78-1)
Recommended Standards
- Dapagliflozin impurity 222 (CAS CATO-C4X-1138222)
- Dapagliflozin Impurity 29 (CAS CATO-C4X-113829)
- Dapagliflozin C2 Epimer (CAS 2133407-75-5)
- Dapagliflozin Impurity 36 (CAS 2040305-05-1)
- Amorolfine Impurity 13(Isomer mixture) (CAS 74880-04-9)
- Cefpirome Impurity 12 (CAS CATO-C4X-120712)
- Omacycline impurity 8 (CAS 2272886-36-7)
- (3-(Benzyloxy)-4-formylphenyl)boronic acid (CAS 1228829-23-9)
- CGI 1746 (CAS 910232-84-7)
- n-Acetyl-n-ethylglycine (CAS 23619-43-4)
- Nalmefene Impurity 17 (CAS CATO-C4X-126817)
- Methyl 2-(2-Hydroxyethyl)benzoate (CAS 1417739-43-5)
- 5-Methyl-2-(3-pyridinyl)-1,3-thiazol-4-yl 3,5-dichlorobenzenecarboxylate (CAS 338398-97-3)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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