Dasatinib Impurity 66 CAS 2468737-89-3
| CAS No. | 2468737-89-3 |
| Molecular Formula | C22H25Cl2N7O2S |
| Molecular Weight | 522.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dasatinib Impurity 66 (CAS 2468737-89-3) is a certified pharmaceutical impurity reference standard with the molecular formula C22H25Cl2N7O2S and a molecular weight of 522.45 g/mol.
Based on its molecular formula C22H25Cl2N7O2S, Dasatinib Impurity 66 contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 522.45 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25Cl2N7O2S |
| Molecular Weight | 522.45 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib Impurity 6 (CAS CATO-C4X-16076)
- Dasatinib Impurity 64 (CAS 2468737-75-7)
- Dasatinib Impurity 65 (CAS 2468737-76-8)
- Dasatinib Impurity 7 (CAS CATO-C4X-16077)
- Dasatinib Impurity 8 (CAS CATO-C4X-16078)
- Dasatinib Impurity 30 (CAS 1417651-54-7)
- Dasatinib Impurity 77 (CAS CATO-C4X-160777)
- Dasatinib Impurity 48 (CAS CATO-C4X-160748)
Recommended Standards
- (S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (CAS 1361224-53-4)
- 1,4-Bis((4-(difluoromethoxy)phenyl)amino)anthracene-9,10-dione (CAS 62149-29-5)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-(sec-butyl)phenyl)acetamide (CAS 618432-39-6)
- (E)-Ethyl 5-(benzyloxy)-6-bromo-1-methyl-2-(2-(phenylthio)vinyl)-1H-indole-3-carboxylate 1704066-47-6 (CAS 1704066-47-6)
- Olopatadine Impurity 28 (CAS 55453-89-9)
- Vericiguat Impurity 23 (CAS CATO-C4X-289623)
- Telmisartan Impurity 49 (CAS 25148-68-9)
- 4,5,6-Trimethylpyridin-2-amine (CAS 142908-13-2)
- N-(3-amino-4-morpholinophenyl)acetamide (CAS 950252-14-9)
- 5-Amino-1-isopropylpiperidin-2-one (CAS 1334148-30-9)
- Rutamine (CAS 485-61-0)
- [5-Amino-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid hydrochloride (CAS 1823547-05-2)
- 2-(1H-indol-3-yl)ethyl-(4-piperidin-1-iumyl)ammonium 2-(1H-indol-3-yl)ethyl-piperidin-1-ium-4-yl-azanium 435342-22-6 A826320 (CAS 435342-22-6)
- Biotinyl-S6 Phosphate Acceptor Peptide trifluoroacetate salt (CAS 1815618-12-2)
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