Dasatinib Impurity 8 CAS CATO-C4X-16078
| CAS No. | CATO-C4X-16078 |
| Molecular Formula | C22H25Cl2N7O2S |
| Molecular Weight | 522.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dasatinib Impurity 8 (CAS CATO-C4X-16078) is a certified pharmaceutical impurity reference standard with the molecular formula C22H25Cl2N7O2S and a molecular weight of 522.45 g/mol.
Structurally, Dasatinib Impurity 8 (C22H25Cl2N7O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 522.45 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dasatinib Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H25Cl2N7O2S |
| Molecular Weight | 522.45 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib Impurity 6 (CAS CATO-C4X-16076)
- Dasatinib Impurity 64 (CAS 2468737-75-7)
- Dasatinib Impurity 65 (CAS 2468737-76-8)
- Dasatinib Impurity 66 (CAS 2468737-89-3)
- Dasatinib Impurity 7 (CAS CATO-C4X-16077)
- Dasatinib Impurity 30 (CAS 1417651-54-7)
- Dasatinib Impurity 77 (CAS CATO-C4X-160777)
- Dasatinib Impurity 48 (CAS CATO-C4X-160748)
Recommended Standards
- (S)-2-(4-(4-((6-Aminopyridin-3-yl)sulfonyl)-2-(prop-1-yn-1-yl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (CAS 1361224-53-4)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-(sec-butyl)phenyl)acetamide (CAS 618432-39-6)
- 3'-[3-(Trifluoromethyl)phenyl]-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione (CAS 865660-60-2)
- 3'-[3-(Trifluoromethyl)phenyl]-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione (CAS 400081-73-4)
- Flunarizine Impurity 27 (CAS 4510-34-3)
- Retigabine impurity 10 (CAS CATO-C4X-13150)
- Luliconazole impurity 29 (CAS CATO-C4X-285329)
- (Z)-O-(3-(Quinolin-3-yl)allyl)hydroxylamine (CAS 628703-64-0)
- 2-Amino-benzothiazole-6-carboxylic acid diethylamide 2-amino-benzothiazole-6-carboxylic acid diethyl amide 2-amino-benzothiazole-6-carboxylic aciddiethylamide 333434-07-4 (CAS 333434-07-4)
- ethyl 1,4-diazepane-1-carboxylate (CAS 18739-39-4)
- Sodium carbosulfonate impurity 29 (CAS CATO-C4X-229129)
- Thioctic Acid Impurity 7 (CAS CATO-C4X-15187)
- hex-2-enal (CAS 505-57-7)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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