2-chloro-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]propanamide CAS 2321768-17-4
| CAS No. | 2321768-17-4 |
| Molecular Formula | C16H16ClN3O4 |
| Molecular Weight | 349.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-chloro-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]propanamide (CAS 2321768-17-4), molecular formula C16H16ClN3O4 and molecular weight 349.77 g/mol, is a CATO reference standard with documented purity and traceability.
2-chloro-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]propanamide (C16H16ClN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16ClN3O4 |
| Molecular Weight | 349.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- 2-(2-Chloro-4-formyl-6-methoxyphenoxy)-N-(2-methoxyphenyl)acetamide (CAS 717892-23-4)
- 3-chloro-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]propanamide (CAS 2321768-15-2)
- n-(4-Chloro-2-methoxyphenyl)-2-(4-formyl-2-methoxyphenoxy)acetamide (CAS 748776-40-1)
- N-(4-Chloro-2-methoxyphenyl)-2-[2-(hydrazinecarbonyl)phenoxy]acetamide (CAS 748776-44-5)
- 5-[1-(4-Chloro-phenyl)-1H-tetrazol-5-yl]-4-phenyl-pyrimidin-2-ylamine (CAS 139393-52-5)
- (2E)-4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-2-[(dimethylamino)methylidene]-3-oxobutanenitrile (CAS 339106-44-4)
- (5Z)-5-{[2-(4-chloro-3-fluorophenoxy)phenyl]methylidene}-1,3-thiazolidine-2,4-dione (CAS 917602-19-8)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(2-(piperidin-1-yl)ethyl)acetamide (CAS 866138-14-9)
Recommended Standards
- ((4-Bromo-2-chloro-3-methylbenzyl)oxy)(tert-butyl)dimethylsilane (CAS 2283377-98-8)
- Loracarbef (CAS 76470-66-1)
- 6-Benzoylamino-4-chloro-2-(4-cyanophenyl amino) pyrimidine (CAS 1404118-66-6)
- 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CAS 1009820-21-6)
- N-(2-(3-(4-Chlorophenyl)-6-oxopyridazin-1(6H)-yl)ethyl)-2-fluorobenzamide (CAS 921851-57-2)
- (3aR,4S,5R,6aS)-4-(tert-Butyldiphenylsilyloxy)methyl-5-tetrahydropyranyloxy-hexahydro-2H-cyclopenta[b]furan-2-one (CAS 92596-29-7)
- n-Benzylbenzenesulfonohydrazide (CAS 1024-31-3)
- 4-(4-Fluorobenzoyl)-N-(furan-2-ylmethyl)-1H-pyrrole-2-carboxamide (CAS 478078-77-2)
- 1-Isobutoxy-3-methylbutane (CAS 92097-02-4)
- 3-Ethyl-4-methylpiperidine (CAS 39191-01-0)
- Methyl 3-(2-cyanophenyl)-5-fluorobenzoate (CAS 1352318-48-9)
- 1-(2-Chlorophenyl)-N,N-diethyl-7-methylisoquinoline-3-carboxamide (CAS 89242-31-9)
- 5-Chloro-2-fluoroisonicotinic acid (CAS 1211532-40-9)
- Hexapeptide-10 (CAS 146439-94-3)
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