Aceclofenac Impurity 18 CAS 2518198-70-2
| CAS No. | 2518198-70-2 |
| Molecular Formula | C22H23Cl2NO6 |
| Molecular Weight | 468.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Aceclofenac Impurity 18 (C22H23Cl2NO6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 468.33 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Aceclofenac Impurity 18 (CAS 2518198-70-2, C22H23Cl2NO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aceclofenac Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H23Cl2NO6 |
| Molecular Weight | 468.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Aceclofenac Standards
- Aceclofenac EP Impurity H (CAS 1216495-92-9)
- Aceclofenac Impurity 14 (CAS CATO-C4X-153114)
- Aceclofenac Benzyl Ester (Aceclofenac EP Impurity F) (CAS 100499-89-6)
- Aceclofenac Impurity 15 (CAS CATO-C4X-153115)
- Aceclofenac Impurity 13 (CAS CATO-C4X-153113)
- Aceclofenac Impurity 16 (CAS CATO-C4X-153116)
- Aceclofenac EP Impurity G (CAS 1215709-75-3)
- Aceclofenac tert-Butyl Ester (CAS 139272-68-7)
Recommended Standards
- (R)-(2-Methyl-4-tert-butylcarbonate)benzene 1-(1-Phenyl-3-iodopropyl) Ether (R)-3-Iodo-1-phenyl-1-[2-methyl-4-[(tert-butoxycarbonyl)-oxy]phenoxy]propane 457634-26-3 Carbonic Acid 1,1-Dimethylethyl 4-[(1R)-3-Iodo-1-phenylpropoxy]-3-methylphenyl Ester (CAS 457634-26-3)
- N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-2-bromo-N-methyl-D-tryptophan (CAS 131791-79-2)
- N'-[2-(2,4-Dichlorophenoxy)ethanimidoyl]-3-[(4-fluorophenyl)methoxy]thiophene-2-carbohydrazide (CAS 338418-83-0)
- 5-Bromo-1-trityl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde (CAS 1481628-10-7)
- Erlotinib Impurity 112 (CAS 99-03-6)
- Metaraminol Impurity 57 (CAS 21480-43-3(free base))
- Oxacillin Impurity 47 (CAS CATO-C4X-232147)
- Methyl 4,5-diaminothiophene-2-carboxylate (CAS 106850-18-4)
- (E)-1-phenyl-3-(5-(p-tolyl)furan-2-yl)prop-2-en-1-one (CAS 40941-07-9)
- Methyl 7-Azaspiro[3.5]nonane-2-carboxylate (CAS 741729-99-7)
- 5-(Methylamino)nicotinic Acid (CAS 91702-88-4)
- 2-(3,5-Dimethyl-4-nitro-1h-pyrazol-1-yl)-N-methylacetamide (CAS 1002695-93-3)
- 4-methoxy-1H-imidazole (CAS 88945-43-1)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com