2-Chloro-3-(trifluoromethyl)quinoline CAS 25199-86-4
| CAS No. | 25199-86-4 |
| Molecular Formula | C10H5ClF3N |
| Molecular Weight | 231.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 231.60 g/mol gives 2-Chloro-3-(trifluoromethyl)quinoline distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-Chloro-3-(trifluoromethyl)quinoline (CAS 25199-86-4), molecular formula C10H5ClF3N and molecular weight 231.60 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-3-(trifluoromethyl)quinoline (C10H5ClF3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-3-(trifluoromethyl)quinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF3N |
| Molecular Weight | 231.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 3-Chloro-7-(trifluoromethyl)quinoline (CAS 104612-21-7)
- 6-Chloro-8-(trifluoromethyl)quinoline (CAS 1065074-68-1)
- 1-chloro-6-(trifluoromethyl)isoquinoline (CAS 1196152-92-7)
- 1-Chloro-7-(trifluoromethyl)isoquinoline (CAS 1196154-02-5)
- 4-Chloro-3-nitrotrifluorotoluene (CAS 121-17-5)
- 8-Chloro-6-(trifluoromethyl)quinoline (CAS 1215206-39-5)
- 1-Chloro-8-trifluoromethyl-isoquinoline (CAS 1283719-92-5)
- 3-Chloro-6-(trifluoromethyl)isoquinoline (CAS 1357945-78-8)
Recommended Standards
- 1-Chloro-5-(trifluoromethyl)isoquinoline (CAS 435278-04-9)
- 2-Chloro-4-(trifluoromethyl)quinoline (CAS 2806-29-3)
- 1-Chloro-4-(trifluoromethyl)isoquinoline (CAS 435278-05-0)
- 2-Chloro-7-(trifluoromethyl)quinoline (CAS 83183-56-6)
- (2R)-1-Benzyl-5-oxo-N-(1-phenylethyl)pyrrolidine-2-carboxamide (CAS 1212481-86-1)
- 3,5-Dimethylphenyl ((2S)-4-(diethylamino)pyrrolidine-2-carbonyl)carbamate (CAS 60309-77-5)
- Imidazo(1,2-a)pyridine-2-carbaldehyde (CAS 118000-43-4)
- n-(2-(Thiophen-3-yl)ethyl)pivalamide (CAS 1060177-67-4)
- 2,2,2-Trifluoroethyl n-(3-chloro-2-fluorophenyl)carbamate (CAS 1087798-10-4)
- rac-(3S,4R)-1-benzyl-4-(1,3-dimethyl-1H-pyrazol-4-yl)pyrrolidine-3-carboxylic acid dihydrochloride (CAS 2059909-42-9)
- 5-fluoro-3,5-ADB-PFUPPYCA (CAS 1969261-68-4)
- (2-methoxy-6-methylpyridin-3-yl)boronic acid (CAS 1000802-75-4)
- 2-Methyl-1-(3-methylphenyl)propan-2-ol (CAS 1754-70-7)
- Semaglutide (CAS CATO-C4X-2226105)
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