Fluticasone Impurity 40 CAS 25256-97-7
| CAS No. | 25256-97-7 |
| Molecular Formula | C20H24F2O3 |
| Molecular Weight | 350.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 350.40 g/mol gives Fluticasone Impurity 40 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Fluticasone Impurity 40 (CAS 25256-97-7), a pharmacopoeial impurity reference standard (molecular formula C20H24F2O3, MW 350.40 g/mol) used for the identification and quantification of trace impurities in APIs.
Fluticasone Impurity 40 (C20H24F2O3) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H24F2O3 |
| Molecular Weight | 350.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | F-containing |
Related Fluticasone Standards
- Fluticasone Impurity 87 (CAS CATO-C4X-165087)
- Fluticasone Impurity N11 (CAS 192191-46-1)
- Fluticasone Impurity 78 (CAS CATO-C4X-165078)
- Fluticasone Impurity 80 (CAS CATO-C4X-165080)
- Fluticasone Impurity N9 (CAS 3863-16-9)
- Fluticasone Impurity N10 (CAS 23961-95-7)
- Fluticasone Impurity 56 (CAS CATO-C4X-165056)
- Fluticasone Impurity 86 (CAS CATO-C4X-165086)
Recommended Standards
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- Lemborexant Impurity 25 (CAS CATO-C4X-304225)
- Aprepitant Impurity 28 (CAS 155742-64-6)
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- 2-(((Cyclopropylmethyl)amino)methyl)-5-methoxyphenol (CAS 1248685-07-5)
- 5-(Benzyloxy)-2-chloro-4-(trifluoromethyl)phenylboronic acid (CAS 2377608-74-5)
- 2-(6-Chloropyridin-2-yl)-2-(2-methoxyphenyl)acetonitrile (CAS 400089-36-3)
- (2S,3R,4R,5S)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-2,3,4-triol (CAS 36468-82-3)
- 3-CHloro-4-methylphenylisocyanide (CAS 112675-35-1)
- Methyl (R)-3-amino-3-(2,5-dichlorophenyl)propanoate (CAS 1213855-87-8)
- Peptide Impurity 82 (CAS 10491-78-8)
Why CATO?
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