Nebivolol Impurity 83 CAS CATO-C4X-196883
| CAS No. | CATO-C4X-196883 |
| Molecular Formula | 2*C18H20FNO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nebivolol Impurity 83 (CAS CATO-C4X-196883) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20FNO2 and a molecular weight of 301.36 g/mol.
The molecular framework of Nebivolol Impurity 83 (C18H20FNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C18H20FNO2 |
| Molecular Weight | 301.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 28 (CAS 112068-01-6)
- D-Nebivolol (SR,RR) (CAS 118457-15-1)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
- Nebivolol Hydrochloride EP Impurity B (CAS 119365-23-0)
- Nebivolol Impurity 32（SS,RS）or（SR,SS） (CAS 119365-25-2)
Recommended Standards
- Avibactam Impurity 60 (CAS CATO-C4X-134860)
- Argatroban Impurity 51 (CAS CATO-C4X-100751)
- Lifitegrast Impurity 114 (CAS CATO-C4X-2409114)
- (2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide 55038-30-7 CTK1H4062 (CAS 55038-30-7)
- 4-Cyclohexyl-5-mercapto-4H-1,2,4-triazol-3-ol (CAS 119185-58-9)
- 2,5-Dichloro-4-[(4-methoxyphenyl)amino]pyrimidine (CAS 698999-78-9)
- 2-Fluoro-6-iodobenzaldehyde (CAS 146137-72-6)
- 2-(3-(Benzyloxy)-6-bromo-2-fluorophenyl)-1,3-dioxolane (CAS 2379321-63-6)
- Ethyl 5-amino-4-iodo-1-(pentan-3-yl)-1H-pyrazole-3-carboxylate (CAS 1427020-21-0)
- Peptide 437 (CAS CATO-CPTD788437)
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