Fosaprepitant Impurity 19 CAS 1623-07-0
| CAS No. | 1623-07-0 |
| Molecular Formula | C7H9O4P |
| Molecular Weight | 188.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fosaprepitant Impurity 19.
As a process- or degradation-related impurity, Fosaprepitant Impurity 19 (CAS 1623-07-0, C7H9O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Fosaprepitant Impurity 19 (C7H9O4P) contains a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 3.5, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 188.12 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H9O4P |
| Molecular Weight | 188.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 41 (CAS 287930-73-8)
- Fosaprepitant Impurity 18 (CAS 252742-72-6)
- Fosaprepitant Impurity 17 (CAS 24021-90-7)
- Fosaprepitant Impurity 874 (CAS 538-37-4)
- Fosaprepitant Impurity 36 (CAS 930-63-2)
- Fosaprepitant Impurity 48 (CAS 1707-92-2)
- Fosaprepitant Impurity 41 HCl (CAS 2377328-02-2)
- Fosaprepitant Dimeglumine (CAS 265121-04-8)
Recommended Standards
- Sofosbuvir Impurity 108 (CAS 4009-39-6)
- 2-(2,5-Difluoro-4-hydroxyphenyl)acetic acid (CAS 1042703-29-6)
- Tetrafluorohydroquinone tetrafluoro-1,4-hydroquinone 1,2,4,5-tetrafluoro-3,6-dihydroxybenzene 2,3,5,6-tetrafluorohydroquinone tetrafluorobenzene-1,4-diol 1,4-dihydroxytetrafluorobenzene 1,4-dihydroxy-2,3,5,6-tetrafluorobenzene 771-63-1 (CAS 771-63-1)
- 2-(3,5-Difluoro-4-hydroxyphenyl)acetic acid (CAS 1042703-32-1)
- Amlodipine Impurity N22 (CAS 39562-06-6)
- Dabigatran Etexilate Impurity 82 (CAS 1771756-20-7)
- Linagliptin Impurity 38 (CAS 1803079-49-3)
- 2-(4-Amino-1,3-dioxoisoindolin-2-yl)acetonitrile (CAS 1016683-43-4)
- 5-Amine-3-(1-oxypyridin-3-yl)-1,2,4-thiadiazole (CAS 1255098-93-1)
- 2,3-dihydro-3-oxo-1H-indene-4-carbonitrile (CAS 215362-26-8)
- N-(3-bromo-2-nitrophenyl)acetamide (CAS 99233-18-8)
- 2-(Chloromethyl)-5-(difluoromethyl)-3-hydroxypyridine-6-carboxaldehyde (CAS 1805535-71-0)
- 4-(2-Methoxyphenyl)-3,7,7-trimethyl-2H,4H,5H,6H,7H,8H,9H-pyrazolo[3,4-b]quinolin-5-one (CAS 866018-94-2)
- [14-31]-Semaglutide (CAS CATO-C4X-2226262)
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