Fosaprepitant Impurity 874 CAS 538-37-4
| CAS No. | 538-37-4 |
| Molecular Formula | C14H14ClOP |
| Molecular Weight | 264.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C14H14ClOP, Fosaprepitant Impurity 874 contains organophosphorus functionality, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 264.69 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Fosaprepitant Impurity 874 (CAS 538-37-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H14ClOP and a molecular weight of 264.69 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fosaprepitant Impurity 874 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H14ClOP |
| Molecular Weight | 264.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 41 (CAS 287930-73-8)
- Fosaprepitant Impurity 19 (CAS 1623-07-0)
- Fosaprepitant Impurity 48 (CAS 1707-92-2)
- Fosaprepitant Impurity 18 (CAS 252742-72-6)
- Fosaprepitant Impurity 17 (CAS 24021-90-7)
- Fosaprepitant Impurity 36 (CAS 930-63-2)
- Fosaprepitant Impurity 30 (CAS 327623-37-0)
- Fosaprepitant Impurity 16 (CAS 327623-34-7)
Recommended Standards
- 5-Amino-1-(2-chloro-4-fluoro-5-methylphenyl)-3-methyl-1H-pyrazole-4-carbonitrile (CAS 2197063-12-8)
- Ethyl 4-chloro-2-(methylsulfonyl)pyrimidine-5-carboxylate (CAS 98490-76-7)
- 4-Chloro-n-ethyl-3-nitrobenzenesulfonamide (CAS 43041-67-4)
- Ethyl 5-chloro-2-(methylsulfonyl)pyrimidine-4-carboxylate (CAS 325723-07-7)
- Edoxaban Impurity 144 (CAS CATO-C4X-1063144)
- Dapagliflozin Impurity 129 (CAS CATO-C4X-1138129)
- Norepinephrine Impurity 10 (CAS 2948-16-5)
- Camelliaside A (CAS 135095-52-2)
- Benzyl (3-(methylamino)propyl)carbamate hydrochloride (CAS 1179362-09-4)
- 7-Chloro-2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 80812-36-8)
- 2-(Methoxymethyl)pyrimidine-4-carboxylic acid (CAS 1092300-06-5)
- 2-Propenoic acid, polymer with 2-ethylhexyl 2-propenoate and 2-propenenitrile (CAS 27233-89-2)
- Ethyl 3-(naphthalen-1-yl)-3-oxopropanoate (CAS 62071-76-5)
- Des-Pro36-37-Tirzepatide (CAS CATO-CPTD788938)
Why CATO?
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