Flurbiprofen Impurity N16 CAS 252846-89-2
| CAS No. | 252846-89-2 |
| Molecular Formula | C18H19FO2 |
| Molecular Weight | 286.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Flurbiprofen Impurity N16 is closely related to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Flurbiprofen Impurity N16 (CAS 252846-89-2), a pharmacopoeial impurity reference standard (molecular formula C18H19FO2, MW 286.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Flurbiprofen Impurity N16 (C18H19FO2) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19FO2 |
| Molecular Weight | 286.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 105 (CAS CATO-C4X-1444105)
- Flurbiprofen Impurity 43 (CAS CATO-C4X-144443)
- Flurbiprofen Impurity 58 (CAS CATO-C4X-144458)
- Flurbiprofen Impurity 55 (CAS 42771-82-4)
- Flurbiprofen Impurity 27 (CAS CATO-C4X-144427)
- Flurbiprofen Impurity 17 (CAS 78543-08-5)
- Flurbiprofen Impurity 22 (CAS 1346604-78-1)
- Flurbiprofen Impurity 111 (CAS CATO-C4X-1444111)
Recommended Standards
- Ethyl 10H-phenothiazin-2-ylcarbamate (CAS 37711-29-8)
- H-His-Met-OH (CAS 2488-11-1)
- Hydroxy Tolbutamide (CAS 5719-85-7)
- H-Met-His-OH (CAS 14486-12-5)
- Levonorgestrel EP Impurity B (CAS 19914-67-1)
- Fluorescein Impurity 15 (CAS 869811-23-4)
- Nefopam Impurity 5 (CAS 13678-16-5)
- 3-Bromo-2,4-dichloro-6-ethoxyquinoline (CAS 1447949-21-4)
- Ethyl 1-(2-bromophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylate (CAS 957044-07-4)
- 2-(3-(Methylsulfonyl)phenyl)pyrrolidine (CAS 1016521-37-1)
- 2-[2-(2,3-Dihydro-2-oxo-4-thiazolyl)ethyl]-1H-isoindole-1,3(2H)-dione (CAS 1504793-34-3)
- (2S)-2-amino-3-(5-ethylthiophen-2-yl)propanoic acid (CAS 909277-27-6)
- 4-Nitrobutanoic acid (CAS 16488-43-0)
- Neuropeptide Y (3-36) (human, rat) trifluoroacetate salt (CAS 150138-78-6)
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