Flurbiprofen Impurity 17 CAS 78543-08-5
| CAS No. | 78543-08-5 |
| Molecular Formula | C14H18FNO4 |
| Molecular Weight | 283.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Flurbiprofen Impurity 17 (CAS 78543-08-5, C14H18FNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Flurbiprofen Impurity 17 (C14H18FNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Flurbiprofen Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H18FNO4 |
| Molecular Weight | 283.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 27 (CAS CATO-C4X-144427)
- Flurbiprofen Impurity 58 (CAS CATO-C4X-144458)
- Flurbiprofen Impurity 105 (CAS CATO-C4X-1444105)
- Flurbiprofen Impurity 43 (CAS CATO-C4X-144443)
- Flurbiprofen Impurity N16 (CAS 252846-89-2)
- Flurbiprofen Impurity 55 (CAS 42771-82-4)
- Flurbiprofen Impurity 22 (CAS 1346604-78-1)
- Flurbiprofen Impurity 111 (CAS CATO-C4X-1444111)
Recommended Standards
- Faropenem Impurity 34 (CAS CATO-C4X-128934)
- Piroxicam EP Impurity K(Meloxicam EP Impurity A) (CAS 24683-26-9)
- Argatroban Impurity 121 (CAS CATO-C4X-1007121)
- Piroxicam Impurity 15 (CAS 208051-67-6)
- N-Nitroso Nafamostat impurity 124 HCl (CAS CATO-C4X-1332124)
- Meropenem Impurity 16 (CAS 137391-68-5)
- Bromfenac Impurity 75 (CAS 91715-34-3)
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- N-Acetylnorfloxacin (CAS 74011-56-6)
- D-Apiose (CAS 639-97-4)
- 17alpha-Estradiol-2,4-d2 (CAS 81586-94-9)
- 2,4-Difluoro-α-methylbenzeneacetonitrile (CAS 1096815-82-5)
- 2-Bromo-3-methylbenzyl Alcohol (CAS 168886-97-3)
- Peptide YY (3-36) (human) (CAS 123583-37-9)
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