Midazolam Impurity 14 CAS 2531288-23-8
| CAS No. | 2531288-23-8 |
| Molecular Formula | C22H17ClFN3O4 |
| Molecular Weight | 441.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Midazolam Impurity 14 (CAS 2531288-23-8), a pharmacopoeial impurity reference standard (molecular formula C22H17ClFN3O4, MW 441.84 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Midazolam Impurity 14 (C22H17ClFN3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Midazolam Impurity 14 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H17ClFN3O4 |
| Molecular Weight | 441.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam Impurity 31 (CAS CATO-C4X-150931)
- Midazolam Impurity 29 (CAS CATO-C4X-150929)
- Midazolam Impurity 30 (CAS CATO-C4X-150930)
- Midazolam Impurity 42 (CAS CATO-C4X-150942)
- Midazolam N-β-D-Glucuronide (~90%, contains ~10% inorganic salts) (CAS 1033824-50-8)
- Midazolam EP Impurity C (CAS 59468-44-9)
- Midazolam Impurity 34 (CAS CATO-C4X-150934)
- Midazolam 2,5-Dioxide-d6 (CAS 1215321-98-4)
Recommended Standards
- 3-((4-(Chlorosulfonyl)-2-nitrophenyl)sulfonyl)benzenesulfonic acid (CAS 90352-55-9)
- 5-((4-Chlorophenyl)thio)-N-(4-methoxyphenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 158712-45-9)
- Rivaroxaban-13C6 (CAS 1261392-59-9)
- (E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrol-2-yl}-N-(4-methylphenyl)ethene-1-sulfonamide (CAS 478080-66-9)
- Vazegepant Impurity 43 (CAS CATO-C4X-320043)
- Tiotropium Bromide EP Impurity H-d3 Bromide (Mixture of Enantiomers) (CAS 1044148-31-3（unlabeled）)
- Olmesartan Impurity 79 (CAS 172875-59-1)
- 1-(4-Methoxyphenyl)-3-((3-nitrophenyl)amino)propan-1-one (CAS 477333-85-0)
- 1-(2-(((2-Aminoethyl)(methyl)amino)methyl)pyrrolidin-1-yl)ethanone (CAS 1353964-13-2)
- 3-Chloro-6-(2-methyl-1H-imidazol-1-yl)pyridazine (CAS 75792-66-4)
- 5288-22-2 8-fluoranyl-2-methyl-1H-quinolin-4-one 8-fluoro-2-methyl-1H-quinolin-4-one A829292 (CAS 5288-22-2)
- 18,19-Dimethoxy-4,5,7,9,13-pentaazapentacyclo[11.8.0.0^{3,11}.0^{4,8}.0^{16,21}]henicosa-3(11),5,7,9,16(21),17,19-heptaen-12-one (CAS 861209-59-8)
- Boc-Ala-ONp (CAS 2483-49-0)
- Des-Ala18-Tirzepatide (CAS CATO-CPTD788955)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com