(E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrol-2-yl}-N-(4-methylphenyl)ethene-1-sulfonamide CAS 478080-66-9
| CAS No. | 478080-66-9 |
| Molecular Formula | C19H15ClF3N3O2S |
| Molecular Weight | 441.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 441.85 g/mol gives (E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrol-2-yl}-N-(4-methylphenyl)ethene-1-sulfonamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrol-2-yl}-N-(4-methylphenyl)ethene-1-sulfonamide (CAS 478080-66-9) is a high-purity analytical reference standard with the molecular formula C19H15ClF3N3O2S and a molecular weight of 441.85 g/mol.
(E)-2-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrol-2-yl}-N-(4-methylphenyl)ethene-1-sulfonamide (C19H15ClF3N3O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H15ClF3N3O2S |
| Molecular Weight | 441.85 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related E Standards
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}phenyl 4-methylbenzene-1-sulfonate (CAS 338416-37-8)
- 2-(2-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)acetyl)-N-methylhydrazine-1-carbothioamide (CAS 306977-97-9)
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((4-ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 618414-35-0)
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573695-56-4)
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((4-ethyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573950-78-4)
- 4-Chloro-N'-(1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carbonyl)benzenesulfonohydrazide (CAS 477709-82-3)
- Ethyl 2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoro-6-methylpyrimidin-4-yl)sulfonyl)acetate (CAS 1823182-28-0)
- (Z)-3-(5-chloro-1,3-diphenyl-1H-pyrazol-4-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile (CAS 956189-95-0)
Recommended Standards
- 5-((4-Chlorophenyl)thio)-N-(4-methoxyphenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 158712-45-9)
- [1-Methyl-5-(phenylsulfanyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl N-(4-chlorophenyl)carbamate (CAS 318239-63-3)
- Midazolam Impurity 14 (CAS 2531288-23-8)
- 3-((4-(Chlorosulfonyl)-2-nitrophenyl)sulfonyl)benzenesulfonic acid (CAS 90352-55-9)
- 3-((4'-Methoxy-[1,1'-biphenyl])-4-sulfonamido)benzoic acid (CAS 885269-91-0)
- 1,4,6-Trichloroanthracene-9,10-dione (CAS 6470-83-3)
- 4-Carbamoyl-1H-imidazol-5-yl benzo[d][1,3]dioxole-5-carboxylate (CAS 66148-63-8)
- Tert-butyl (R)-((2-(cyclopropylmethyl)pyrrolidin-2-yl)methyl)carbamate (CAS 2306246-22-8)
- Benzene,1-(1,1-dimethylethyl)-4-(methylthio) (CAS 7252-86-0)
- Tert-butyl (R)-(2-(4-benzylmorpholin-2-yl)ethyl)carbamate (CAS 2381617-07-6)
- 3-Ethyl-2-((3-(trifluoromethyl)benzyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 578722-36-8)
- Finerenone Impurity 249 (CAS CATO-C4X-2880249)
- Tizanidine Impurity 38 (CAS CATO-C4X-144538)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
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