Midazolam Impurity 42 CAS CATO-C4X-150942
| CAS No. | CATO-C4X-150942 |
| Molecular Formula | C21H20ClFN2O2 |
| Molecular Weight | 386.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Midazolam Impurity 42 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 386.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Midazolam Impurity 42 (CAS CATO-C4X-150942) is a certified pharmaceutical impurity reference standard with the molecular formula C21H20ClFN2O2 and a molecular weight of 386.85 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H20ClFN2O2 |
| Molecular Weight | 386.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Midazolam Standards
- Midazolam Impurity 30 (CAS CATO-C4X-150930)
- Midazolam EP Impurity C (CAS 59468-44-9)
- Midazolam Impurity 34 (CAS CATO-C4X-150934)
- Midazolam 2,5-Dioxide-d6 (CAS 1215321-98-4)
- Midazolam Hydrochloride (CAS 59467-96-8)
- Midazolam Impurity 19 (CAS CATO-C4X-150919)
- Midazolam Impurity 18 (CAS CATO-C4X-150918)
- Midazolam Impurity 20 (CAS 151921-06-1)
Recommended Standards
- Methyl 1-(4-chlorophenyl)-6-oxo-4-(p-tolylthio)-1,6-dihydropyridazine-3-carboxylate (CAS 338405-77-9)
- 100826-98-0 2-[4-(2-Chlorophenyl)-9-methyl-6H-thieno-[3,2-f][1,2,4]-triazolo[4,3-a][1,4]diazepin-2-yl]ethane-1-carboxylic Acid 4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-2-propanoic Acid Desbromo Brotizolam 2-Propanoic Acid (CAS 100826-98-0)
- 3-(2-Chloro-6-fluorophenyl)-5-methyl-N-[3-methyl-4-(propan-2-yl)phenyl]-1,2-oxazole-4-carboxamide (CAS 866150-66-5)
- 2,3-Dibromo-2-(4-bromophenyl)propionic Acid (CAS 112595-55-8)
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- 2-[(carboxymethyl)dimethylazaniumyl]acetate (CAS 30163-90-7)
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- D-[Asp]9-Semaglutide (CAS CATO-CPTD788631)
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