Lansoprazole Impurity 17 CAS 253345-80-1
| CAS No. | 253345-80-1 |
| Molecular Formula | C9H10F3NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Lansoprazole Impurity 17 (C9H10F3NO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 257.64 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Lansoprazole Impurity 17 (CAS 253345-80-1, C9H10F3NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H10F3NO2 HCl |
| Molecular Weight | 257.64 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Lansoprazole Standards
- Lansoprazole EP Impurity D (CAS 102976-62-5)
- Lansoprazole Impurity 37 (CAS 103312-62-5)
- Lansoprazole EP Impurity C/USP Impurity B (CAS 103577-40-8)
- Lansoprazole (CAS 103577-45-3)
- Lansoprazole Impurity 45 (CAS 103577-61-3)
- Lansoprazole Impurity 51 (CAS 103577-66-8)
- Lansoprazole Impurity 18 (CAS 1083100-26-8)
- Lansoprazole Impurity 10 (CAS 1083100-27-9)
Recommended Standards
- Caspofungin Impurity B (CAS CATO-C4X-15756)
- Celecoxib Impurity 25 (CAS CATO-C4X-104325)
- Carbazochrome Impurity 13 (CAS CATO-C4X-229113)
- trans-4-Amino-1-benzyl-3-(hydroxymethyl)piperidine (CAS 1260670-31-2)
- Ethyl 3,4,5-triethoxybenzoate (CAS 31374-71-7)
- tert-Butyl 4-(4-hydroxybutyl)piperazine-1-carboxylate (CAS 1155269-82-1)
- Mavacamten Impurity 18 (CAS CATO-C4X-298218)
- 2-((2-(Aminomethyl)piperidin-1-yl)methyl)benzonitrile hydrochloride (CAS 1353987-15-1)
- 4-Amino-5-(difluoromethyl)-3-fluoropicolinoyl chloride (CAS 1806813-89-7)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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