4-Chlorobenzo[d]isothiazol-3-amine CAS 25380-80-7
| CAS No. | 25380-80-7 |
| Molecular Formula | C7H5ClN2S |
| Molecular Weight | 184.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chlorobenzo[d]isothiazol-3-amine (CAS 25380-80-7), molecular formula C7H5ClN2S and molecular weight 184.65 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system, 4-Chlorobenzo[d]isothiazol-3-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 184.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClN2S |
| Molecular Weight | 184.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorobenzo Standards
- 7-Chlorobenzo[d]thiazol-5-amine (CAS 196205-26-2)
- 2-Chlorobenzo[d]thiazol-4-amine (CAS 855283-00-0)
- 2-Chlorobenzo[d]thiazol-6-amine (CAS 2406-90-8)
- 4-Chlorobenzo[d]isothiazol-7-amine (CAS 35271-94-4)
- 4-Chlorobenzo[d]thiazol-5-amine (CAS 70202-01-6)
- 4-Chlorobenzo[d]thiazol-7-amine (CAS 70202-02-7)
- 5-Chlorobenzo[c]isothiazol-3-amine (CAS 51357-79-0)
- 5-Chlorobenzo[d]isothiazol-3-amine (CAS 69504-56-9)
Recommended Standards
- 4-Chloro-2-methylthiazolo[4,5-c]pyridine (CAS 936477-32-6)
- 4-Chloro-1H-benzo[d]imidazole-2(3H)-thione (CAS 75335-72-7)
- 4-Amino-2-chlorophenyl thiocyanate (CAS 3226-46-8)
- 4-(5-Chlorothiophen-2-yl)-1h-pyrazole (CAS 76153-69-0)
- 2-Acetyl-3,5-bis(benzyloxy)phenol (CAS 18065-05-9)
- (2R,3R,4S,5S,6R)-2-(acetoxymethyl)-6-(p-tolylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 211801-79-5)
- Tert-butyl n-[4-(aminomethyl)phenyl]-N-methylcarbamate (CAS 1040682-07-2)
- 5-Bromo-N-(4-bromobenzo[d]thiazol-2-yl)thiophene-2-carboxamide (CAS 892857-21-5)
- Diethyl 1-(2-oxo-2-(3-phenylureido)ethyl)-1H-1,2,3-triazole-4,5-dicarboxylate (CAS 892278-36-3)
- 4-(2-Oxopyrrolidin-1-yl)-3-(trifluoromethyl)benzaldehyde (CAS 1260800-57-4)
- Nifekalant impurity 6 (CAS CATO-C4X-27976)
- 5-Ethynyl-2-(trifluoromethyl)pyridine (CAS 1196155-24-4)
- 4-(Piperazinyl)benzoic acid dihydrochloride, 97% (CAS 354813-11-9)
- Dulaglutide (CAS 923950-08-7)
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