Levothyroxine Sodium CAS 25416-65-3
| CAS No. | 25416-65-3 |
| Molecular Formula | C15H10I4NNaO4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies Levothyroxine Sodium (CAS 25416-65-3), a certified reference material (molecular formula C15H10I4NNaO4H2O, MW 816.85 g/mol) for analytical method development and quality control.
Structurally, Levothyroxine Sodium (C15H10I4NNaO4H2O) contains a salt form, a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.5, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 816.85 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Levothyroxine Sodium meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10I4NNaO4 H2O |
| Molecular Weight | 816.85 g/mol |
| Purity | >80% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine Impurity 36 (CAS 100130-56-1)
- Levothyroxine Impurity 38 (CAS 1027-28-7)
- Levothyroxine EP Impurity E (CAS 1041-01-6)
- Levothyroxine Impurity 14 (CAS 10468-90-3)
- Levothyroxine Impurity 49 (CAS 106822-80-4)
- Levothyroxine Impurity 30 (CAS 107849-54-7)
- Levothyroxine Impurity 18 (CAS 1155-40-4)
- Levothyroxine EP Impurity B (CAS 1628720-66-0)
Recommended Standards
- Methyl 4-((8-chloro-2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl)benzoate (CAS 1354547-26-4)
- 5-Hydroxyuridine (CAS 957-77-7)
- 4-Amino-N-cyclopropyl-3-methoxybenzamide (CAS 946826-55-7)
- 1-(3-Iodophenyl)-1H-pyrrole-2,5-dione (CAS 135861-54-0)
- 3-(3-methylpyridin-2-yl)propan-1-amine (CAS 1000512-96-8)
- 9,9-Didodecylfluorene-2,7-diboronic acid (CAS 480424-86-0)
- 4-(Chloromethyl)-N-(1H-1,2,4-triazol-3-yl)benzamide (CAS 916791-21-4)
- 6-Acetamido-2-methyl-3-nitrobenzoic acid (CAS 90321-36-1)
- 4-Bromo-3-fluorophenyl cyclopropyl ketone (CAS 898790-03-9)
- Endo-Pro36-Tirzepatide (CAS CATO-CPTD788688)
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