Levothyroxine Impurity 38 CAS 1027-28-7
| CAS No. | 1027-28-7 |
| Molecular Formula | C11H11I2NO4 |
| Molecular Weight | 475.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Levothyroxine Impurity 38 (CAS 1027-28-7) is a certified pharmaceutical impurity reference standard with the molecular formula C11H11I2NO4 and a molecular weight of 475.02 g/mol.
Based on its molecular formula C11H11I2NO4, Levothyroxine Impurity 38 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 475.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Levothyroxine Impurity 38 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H11I2NO4 |
| Molecular Weight | 475.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine Impurity 18 (CAS 1155-40-4)
- Levothyroxine Impurity 16 (CAS 4192-14-7)
- rac-Levothyroxine EP Impurity J (3,3'-DL-Diiodothyronine) (CAS 70-40-6)
- Levothyroxine EP Impurity J (CAS 4604-41-5)
- Levothyroxine EP Impurity E (CAS 1041-01-6)
- Levothyroxine Impurity 43 (CAS 854646-83-6)
- Levothyroxine Impurity 37 (CAS 94345-95-6)
- Levothyroxine Impurity 36 (CAS 100130-56-1)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com