Levothyroxine EP Impurity E CAS 1041-01-6
| CAS No. | 1041-01-6 |
| Molecular Formula | C15H13I2NO4 |
| Molecular Weight | 525.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Levothyroxine EP Impurity E (CAS 1041-01-6, C15H13I2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H13I2NO4, Levothyroxine EP Impurity E contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 525.08 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Levothyroxine EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H13I2NO4 |
| Molecular Weight | 525.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine Impurity 16 (CAS 4192-14-7)
- rac-Levothyroxine EP Impurity J (3,3'-DL-Diiodothyronine) (CAS 70-40-6)
- Levothyroxine EP Impurity J (CAS 4604-41-5)
- Levothyroxine Impurity 37 (CAS 94345-95-6)
- Levothyroxine Impurity 18 (CAS 1155-40-4)
- Levothyroxine Impurity 38 (CAS 1027-28-7)
- Levothyroxine Impurity 58 (CAS 176258-87-0)
- Levothyroxine Impurity 42 (CAS 4618-45-5)
Recommended Standards
- 7-(5-((tert-Butyldiphenylsilyl)oxy)-2-chlorophenyl)-5-methylbenzo[e][1,2,4]triazin-3-amine (CAS 1245644-51-2)
- VTP 27999 (CAS 942142-51-0)
- 4-(bis(4-Iodophenyl)amino)benzaldehyde (CAS 808758-81-8)
- (3-(3-Amino-2,6-difluorobenzoyl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone (CAS 1501153-67-8)
- Atropine Impurity 22 (CAS 16052-33-8)
- Ipratropium Bromide EP Impurity B (CAS 58073-59-9)
- Ticlopidine EP Impurity L (CAS 68559-55-7)
- Resmetirom Impurity 92 (CAS CATO-C4X-291292)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrrole-2-carbaldehyde (CAS 321430-69-7)
- 1,2-Bis(di-p-tolylphosphaneyl)ethane (CAS 70320-30-8)
- Mezlocillin Impurity 13 (CAS CATO-C4X-183113)
- 2-((2,4-Dimethylbenzyl)thio)-1H-benzo[d]imidazole (CAS 295361-85-2)
- tert-butyl (2R,4S)-2,4-bis(methylsulfonyloxymethyl)azetidine-1-carboxylate (CAS 2387562-32-3)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com