Venetoclax Impurity 28 CAS 2573767-93-6
| CAS No. | 2573767-93-6 |
| Molecular Formula | C80H85Cl2N11O10S |
| Molecular Weight | 1463.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Venetoclax Impurity 28 (CAS 2573767-93-6) is a certified pharmaceutical impurity reference standard with the molecular formula C80H85Cl2N11O10S and a molecular weight of 1463.57 g/mol.
The molecular framework of Venetoclax Impurity 28 (C80H85Cl2N11O10S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C80H85Cl2N11O10S |
| Molecular Weight | 1463.57 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 43.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 11 |
| Sulfur Atoms | 1 |
Related Venetoclax Standards
- Venetoclax Impurity 20 (CAS 2270190-88-8)
- Venetoclax Impurity 46 (CAS CATO-C4X-249546)
- Venetoclax Impurity 111 (CAS CATO-C4X-2495111)
- Venetoclax Impurity 116 (CAS CATO-C4X-2495116)
- Venetoclax Impurity 34 (CAS 2573767-94-7)
- Venetoclax Impurity 26 (CAS 2412506-53-5)
- Venetoclax Impurity 63 (CAS CATO-C4X-249563)
- Venetoclax Impurity 29 (CAS CATO-C4X-249529)
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