Venetoclax Impurity 46 CAS CATO-C4X-249546

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-249546
Molecular FormulaC78H83Cl2N11O9S
Molecular Weight1421.53 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Venetoclax Impurity 46 CAS CATO-C4X-249546 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Venetoclax Impurity 46.

CATO supplies Venetoclax Impurity 46 (CAS CATO-C4X-249546), a pharmacopoeial impurity reference standard (molecular formula C78H83Cl2N11O9S, MW 1421.53 g/mol) used for the identification and quantification of trace impurities in APIs.

Structurally, Venetoclax Impurity 46 (C78H83Cl2N11O9S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 42.0, corresponding to approximately 42 ring(s) or double-bond equivalent(s). With a molecular weight of 1421.53 g/mol, it falls into the high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

CATO manufactures Venetoclax Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC78H83Cl2N11O9S
Molecular Weight1421.53 g/mol
Purity97%+
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)42.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms11
Sulfur Atoms1

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