4-Chloro-3-(trifluoromethyl)cinnamic acid CAS 257872-87-0
| CAS No. | 257872-87-0 |
| Molecular Formula | C10H6ClF3O2 |
| Molecular Weight | 250.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-3-(trifluoromethyl)cinnamic acid.
CATO supplies 4-Chloro-3-(trifluoromethyl)cinnamic acid (CAS 257872-87-0), a certified reference material (molecular formula C10H6ClF3O2, MW 250.60 g/mol) for analytical method development and quality control.
Based on its molecular formula C10H6ClF3O2, 4-Chloro-3-(trifluoromethyl)cinnamic acid contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 250.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-3-(trifluoromethyl)cinnamic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6ClF3O2 |
| Molecular Weight | 250.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-(3-Chloro-2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)propanenitrile (CAS 1053658-44-8)
- 6-Chloro-7-(trifluoromethyl)chroman-4-one (CAS 1092349-68-2)
- 3-Chloro-4-(trifluoromethyl)cinnamic acid (CAS 1092460-80-4)
- (8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)methanol (CAS 1216024-49-5)
- 6-Chloro-8-(trifluoromethyl)chroman-4-one (CAS 1344889-75-3)
- (E)-3-(2-Chloro-5-(trifluoromethyl)phenyl)acrylic acid (CAS 1386504-00-2)
- 3-Chloro-5-(trifluoromethyl)cinnamic acid (CAS 1588508-15-9)
- 2-Chloro-4,4,4-trifluoro-1-phenylbutane-1,3-dione (CAS 163667-29-6)
Recommended Standards
- 3-[4-(Trifluoromethoxy)phenyl]acryloyl chloride (CAS 306936-02-7)
- 4-Chloro-1-methyl-3-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1245643-17-7)
- 3-(4-Chloro-3-(trifluoromethyl)phenyl)acrylic acid (CAS 58537-09-0)
- 6-Chloro-7,8-dimethyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1394040-15-3)
- 6-Iodochromane (CAS 67856-45-5)
- 6-tert-Butylquinolin-4-ol (CAS 444609-92-1)
- 4-Fluorophenyl chloroformate (CAS 38377-38-7)
- 4-Propoxypyrimidine (CAS 45815-15-4)
- 2-{[4-(tert-Butyl)benzyl]sulfanyl}-3-quinolinecarbaldehyde (CAS 478065-52-0)
- 2-Cyclopentylpyrimidine-4-carboxylic acid (CAS 1341862-89-2)
- (2-Bromo-3,4-difluorophenyl)methanamine hydrochloride (CAS 2231675-44-6)
- Methyl 4-amino-1-(3-methoxypropyl)-1h-pyrrole-2-carboxylate (CAS 1248437-67-3)
- 1-(5-Chloro-2-methylphenyl)-5-methyl-N-(2-(methylthio)phenyl)-1H-1,2,3-triazole-4-carboxamide (CAS 904817-46-5)
- Tirzepatide Impurity 34 (CAS CATO-C4X-324034)
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