3-(Chloromethyl)-1,2,4-oxadiazole-5-carboxamide CAS 25977-21-3
| CAS No. | 25977-21-3 |
| Molecular Formula | C4H4ClN3O2 |
| Molecular Weight | 161.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3-(Chloromethyl)-1,2,4-oxadiazole-5-carboxamide (C4H4ClN3O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
3-(Chloromethyl)-1,2,4-oxadiazole-5-carboxamide (CAS 25977-21-3) is a high-purity analytical reference standard with the molecular formula C4H4ClN3O2 and a molecular weight of 161.55 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(Chloromethyl)-1,2,4-oxadiazole-5-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4ClN3O2 |
| Molecular Weight | 161.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloromethyl Standards
- 1-(Chloromethyl)-3-nitro-1H-pyrazole (CAS 102388-00-1)
- 1-(Chloromethyl)-4-nitro-1h-pyrazole (CAS 51355-88-5)
- 5-(Chloromethyl)-1,2,4-oxadiazole-3-carboxamide (CAS 34879-29-3)
- 6-(Chloromethyl)-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione (CAS 24753-63-7)
- 4-(Chloromethyl)-5-fluoropyridin-2-ol (CAS 1227584-62-4)
- 2-(Chloromethyl)-6-fluoropyridin-4-ol (CAS 1393540-63-0)
- 2-(Chloromethyl)oxazole-4-carboxylic acid (CAS 208465-62-7)
- 2-(Chloromethyl)oxazole-5-carboxylic acid (CAS 481667-42-9)
Recommended Standards
- 2-chloro-N-(1H-1,2,3,4-tetrazol-5-yl)acetamide (CAS 6158-78-7)
- 3-Chloro-1-methyl-4-nitro-1H-pyrazole (CAS 299930-70-4)
- 2-Chloro-1-methyl-5-nitro-1H-imidazole (CAS 86072-07-3)
- 4-Chloro-1-methyl-2-nitro-1H-imidazole (CAS 63634-20-8)
- 5-(Azepan-1-yl)-2-(methylsulfonyl)aniline (CAS 942474-92-2)
- N-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-phenylpropyl)benzamide (CAS 300680-23-3)
- 1-Butylpiperazin-2-one (CAS 59702-09-9)
- 2-(Pyridin-2-yl)-1,3-thiazole-4-carbaldehyde (CAS 173838-60-3)
- 3-(Methylthio)-5-phenyl-1,2,4-triazine (CAS 28735-27-5)
- 5-Chloropentylzinc bromide 0.5 M in Tetrahydrofuran (CAS 312624-21-8)
- Ethyl 7-Aminoquinoline-2-carboxylate (CAS 1447607-02-4)
- N-Butyl-N-(3-ethyl-1,2,4-oxadiazol-5-yl)cyclopropanecarboxamide (CAS 62385-87-9)
- Pirfenidone Impurity 27 (CAS 109285-68-7)
- Integrin Binding Peptide trifluoroacetate salt (CAS 278792-07-7)
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