Naproxen EP Impurity E CAS 26159-35-3
| CAS No. | 26159-35-3 |
| Molecular Formula | C15H16O3 |
| Molecular Weight | 244.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Naproxen EP Impurity E.
CATO supplies Naproxen EP Impurity E (CAS 26159-35-3), a pharmacopoeial impurity reference standard (molecular formula C15H16O3, MW 244.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Naproxen EP Impurity E (C15H16O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 244.29 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Naproxen EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H16O3 |
| Molecular Weight | 244.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
Related Naproxen Standards
- (+/-)-naproxen-(methoxy-d3) 958293-79-3 (CAS 958293-79-3)
- rac Naproxen-d3 Methyl Ester (CAS 1189511-76-9)
- Naproxen Impurity 50 (CAS CATO-C4X-170850)
- Naproxen Impurity 54 (CAS 1268842-11-0)
- Naproxen EP Impurity N (CAS 5111-65-9)
- rac-Naproxen-13C,d3 (CAS 1216704-11-8)
- (S)-Naproxen-d3 (CAS 1094102-82-5)
- Naproxen Impurity 45 (CAS CATO-C4X-170845)
Recommended Standards
- Doxofylline impurity 46 (CAS CATO-C4X-151346)
- S-(-)-Etomidate (CAS 56649-47-9)
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- Peridine Impurity 14 (CAS 252720-31-3)
- Fudosteine Impurity 21 (Mixture of Diastereomers) (CAS 209665-22-5)
- Letermovir Impurity N19 (CAS 791117-40-3)
- Ezetimibe Impurity 125 (CAS 439080-96-3)
- 2,3-Dichloropyridine1-oxide (CAS 53976-65-1)
- 4-(Benzyloxy)-8-methoxy-2-methylquinoline (CAS 1081799-68-9)
- (E)-2-(2-Oxoindolin-3-ylidene)acetonitrile (CAS 40313-84-6)
- Ethyl 1-(4-chlorophenyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridazine-3-carboxylate (CAS 251557-24-1)
- 3-Methyl-4-oxopent-2-enoic acid (CAS 53663-10-8)
- (S)-3-((tert-Butoxycarbonyl)amino)-4-(4-(trifluoromethyl)phenyl)butanoic acid (CAS 270065-80-0)
- Semaglutide impound 212 (CAS CATO-C4X-2226212)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com