Ezetimibe Impurity 125 CAS 439080-96-3
| CAS No. | 439080-96-3 |
| Molecular Formula | C20H20FNO4 |
| Molecular Weight | 357.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ezetimibe Impurity 125 (CAS 439080-96-3) is a certified pharmaceutical impurity reference standard with the molecular formula C20H20FNO4 and a molecular weight of 357.38 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Ezetimibe Impurity 125 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 357.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H20FNO4 |
| Molecular Weight | 357.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 139 (CAS CATO-C4X-1098139)
- Ezetimibe Impurity 24 (CAS 528565-93-7)
- Ezetimibe Impurity 25 (CAS 404874-94-8)
- Ezetimibe Impurity 26 (CAS 1612153-32-8)
- Ezetimibe Impurity 42 (CAS 189028-95-3)
- Ezetimibe Impurity 93 (CAS CATO-C4X-109893)
- Ezetimibe Impurity 36 (CAS 189028-93-1)
- Ezetimibe Impurity 38 (CAS 404874-93-7)
Recommended Standards
- Axitinib Impurity 77 (CAS CATO-C4X-107177)
- Axitinib Impurity 55 (CAS CATO-C4X-107155)
- Trelagliptin impurity 87 (CAS 2270843-82-6)
- Trelagliptin impurity 81 (CAS CATO-C4X-104681)
- Azelastine Impurity 30 (CAS 117078-70-3)
- Budesonide Impurity 27 (CAS 2396-43-2)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
- 2-Hydrazinyl-N,N,6-trimethylpyrimidin-4-amine (CAS 63206-75-7)
- Pyrazolo[1,5-a]pyridin-7-amine (CAS 1554453-28-9)
- 4-(Furan-2-yl)-1H-pyrrole-3-carboxylic acid (CAS 1188029-07-3)
- 6-Methyl-3-((methylamino)methyl)quinolin-2-ol (CAS 673492-96-1)
- Methyl 1-(bromomethyl)cyclobutane-1-carboxylate (CAS 41384-63-8)
- N-Desacetyl 5-Azido OseltaMivir (CAS 204255-04-9)
- [γ-Glu]15 Semaglutide (CAS CATO-C4X-222690)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com