Naproxen Impurity 50 CAS CATO-C4X-170850
| CAS No. | CATO-C4X-170850 |
| Molecular Formula | C14H13ClO2 |
| Molecular Weight | 248.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Naproxen Impurity 50 (CAS CATO-C4X-170850, C14H13ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Naproxen Impurity 50 (C14H13ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 248.70 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Naproxen Impurity 50 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H13ClO2 |
| Molecular Weight | 248.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Naproxen Standards
- rac Naproxen-d3 Methyl Ester (CAS 1189511-76-9)
- Naproxen EP Impurity E (CAS 26159-35-3)
- (+/-)-naproxen-(methoxy-d3) 958293-79-3 (CAS 958293-79-3)
- Naproxen Impurity 45 (CAS CATO-C4X-170845)
- Naproxen Impurity 5 (CAS 37961-57-2)
- Naproxen EP Impurity F (CAS 31220-35-6)
- 51091-84-0 Naproxen acid chloride d-2-(6-Methoxy-2-naphthyl)propionyl chloride Naproxen chloride (CAS 51091-84-0)
- Naproxen Impurity 54 (CAS 1268842-11-0)
Recommended Standards
- 65250-18-2 2-Methyl-2-(2-naphthyloxy)propanoyl chloride MFCD11916324 (CAS 65250-18-2)
- 5-Chloro-2-methoxy-N-(pyridin-3-ylmethyl)aniline (CAS 1019609-30-3)
- 4-Benzyloxy-2-chlorobenzyl alcohol (CAS 219764-60-0)
- 5-(1H-pyrazol-3-yl)thiophene-2-sulfonyl chloride (CAS 1030288-73-3)
- 【停用见C1650856】Pitolisant Impurity 52 (CAS CATO-C4X-252052)
- Lansoprazole Impurity 60 (CAS CATO-C4X-111360)
- Beclometasone Dipropionate EP Impurity N (CAS 1204582-47-7)
- Ethyl 2-[(3,5-dichloropyridin-2-yl)sulfonyl]acetate (CAS 478049-31-9)
- 4-(4-Cyclohexylphenyl)-4-oxo-2-(pyrrolidin-1-yl)butanoic acid (CAS 303090-92-8)
- (R)-1-[4-[6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one (CAS 1698055-86-5)
- Hyoscine EP Impurity A (CAS 4684-28-0)
- 3-(Cyclopropylmethoxy)-2-iodophenol (CAS 1243322-65-7)
- 1-(3,4-Dihydro-2H-1,4-Thiazin-6-Yl)-2,2,2-Trifluoroethanone (CAS 345900-58-5)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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