4-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-2-(4-chlorophenyl)-1,3-thiazole CAS 262439-68-9
| CAS No. | 262439-68-9 |
| Molecular Formula | C22H14Cl2N2O4S2 |
| Molecular Weight | 505.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-2-(4-chlorophenyl)-1,3-thiazole.
CATO supplies 4-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-2-(4-chlorophenyl)-1,3-thiazole (CAS 262439-68-9), a certified reference material (molecular formula C22H14Cl2N2O4S2, MW 505.39 g/mol) for analytical method development and quality control.
The molecular framework of 4-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-2-(4-chlorophenyl)-1,3-thiazole (C22H14Cl2N2O4S2) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H14Cl2N2O4S2 |
| Molecular Weight | 505.39 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related chlorobenzenesulfonyl Standards
- 3-(4-Chlorobenzenesulfonyl)-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine (CAS 339103-52-5)
- 5-[1-(4-Chlorobenzenesulfonyl)piperidin-4-yl]-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazole-3-thiol (CAS 478042-32-9)
- 1-(4-Chlorobenzenesulfonyl)-N'-[(1E)-(4-phenoxyphenyl)methylidene]piperidine-4-carbohydrazide (CAS 478030-76-1)
- (2E)-2-(4-Chlorobenzenesulfonyl)-3-{2-[(4-chlorophenyl)sulfanyl]-5-nitrophenyl}prop-2-enenitrile (CAS 1025281-49-5)
- N-{4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-3-methylbenzamide (CAS 478260-29-6)
- (2E)-1-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-3-[(4-methoxyphenyl)amino]prop-2-en-1-one (CAS 338968-32-4)
- 7-[4-(4-Chlorobenzenesulfonyl)piperazin-1-yl]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 320417-95-6)
- 3-(4-Chlorobenzenesulfonyl)-N-[(3-methoxyphenyl)methyl]-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 895646-96-5)
Recommended Standards
- (S)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-(4-iodophenyl)-N-phenylpyrrolidine-2-carboxamide (CAS 371919-42-5)
- 5-(3,4-Dichlorophenyl)-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one (CAS 489405-46-1)
- 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine (CAS 1383446-11-4)
- Ethyl 3-(2-chloro-6-fluorophenyl)-2-(2-((3-chlorobenzyl)thio)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)propanoate (CAS 477860-57-4)
- Sodium 2,3,4-trifluorobenzoate (CAS 402955-41-3)
- 3-Bromo-5-chloro-1-tosyl-1H-indole (CAS 887338-49-0)
- Methyl 3-((4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl)amino)propanoate (CAS 1183464-17-6)
- 5-(4-Iodophenyl)thiophene-2-carbaldehyde (CAS 887987-37-3)
- Methyl 4-amino-1-(2-methoxy-2-oxoethyl)-1h-pyrrole-2-carboxylate (CAS 1247238-35-2)
- N-Ethyl-N-[2-methoxy-4-[5-methyl-4-[[(1S)-1-(3-pyridinyl)butyl]amino]-2-pyrimidinyl]phenyl]urea (CAS 917111-44-5)
- N-(2,2,2-trifluoroethyl)-1H-1,3-benzodiazole-5-carboxamide (CAS 1110885-03-4)
- 3-(Benzylamino)-1,1,1-trifluoropropan-2-ol (CAS 178218-36-5)
- Ethyl 5-acetoxy-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-carboxylate (CAS 53252-54-3)
- Tirzepatide Impurity 38 (CAS CATO-C4X-324038)
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