3-(4-Chlorobenzenesulfonyl)-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine CAS 339103-52-5
| CAS No. | 339103-52-5 |
| Molecular Formula | C25H17ClF3NO3S |
| Molecular Weight | 503.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(4-Chlorobenzenesulfonyl)-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(4-Chlorobenzenesulfonyl)-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine (CAS 339103-52-5) is a high-purity analytical reference standard with the molecular formula C25H17ClF3NO3S and a molecular weight of 503.92 g/mol.
3-(4-Chlorobenzenesulfonyl)-4-methyl-6-phenyl-2-[3-(trifluoromethyl)phenoxy]pyridine (C25H17ClF3NO3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H17ClF3NO3S |
| Molecular Weight | 503.92 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlorobenzenesulfonyl Standards
- 5-[1-(4-Chlorobenzenesulfonyl)piperidin-4-yl]-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazole-3-thiol (CAS 478042-32-9)
- 4-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-2-(4-chlorophenyl)-1,3-thiazole (CAS 262439-68-9)
- 1-(4-Chlorobenzenesulfonyl)-N'-[(1E)-(4-phenoxyphenyl)methylidene]piperidine-4-carbohydrazide (CAS 478030-76-1)
- (2E)-2-(4-Chlorobenzenesulfonyl)-3-{2-[(4-chlorophenyl)sulfanyl]-5-nitrophenyl}prop-2-enenitrile (CAS 1025281-49-5)
- N-{4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]-3-fluorophenyl}-3-methylbenzamide (CAS 478260-29-6)
- (2E)-1-{3-[(4-chlorobenzenesulfonyl)methyl]-4-nitrophenyl}-3-[(4-methoxyphenyl)amino]prop-2-en-1-one (CAS 338968-32-4)
- 7-[4-(4-Chlorobenzenesulfonyl)piperazin-1-yl]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 320417-95-6)
- 3-(4-Chlorobenzenesulfonyl)-N-[(3-methoxyphenyl)methyl]-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 895646-96-5)
Recommended Standards
- (E)-{[4-(4-chlorophenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5-trien-3-yl]methylidene}amino 3-(trifluoromethyl)benzoate (CAS 383147-91-9)
- Diethyl 5-((R)-2-((R)-5-(3-chlorophenyl)-2-oxooxazolidin-3-yl)propyl)benzo[d][1,3]dioxole-2,2-dicarboxylate (CAS 139013-14-2)
- 338960-73-9 4-({[(4-chlorophenyl)methyl]sulfanyl}methyl)-6-[(2,6-dichlorophenyl)sulfanyl]-2-phenylpyrimidine 5L-509S (CAS 338960-73-9)
- 2-(2-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)acetyl)-N-phenylhydrazine-1-carbothioamide (CAS 339099-35-3)
- Ethyl 7-(2-methoxy-2-oxoethyl)-4-(thiophene-2-sulfonyl)-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate (CAS 866134-83-0)
- (5-bromo-1-methyl-pyrazol-3-yl)methyl methanesulfonate (CAS 2303766-93-8)
- 1-((3R,4S)-3,4-Diaminopyrrolidin-1-yl)ethanone (CAS 380357-19-7)
- Aprepitant impurity 53 (CAS 502537-39-5)
- Promethazine Impurity 39 (CAS 857523-80-9)
- 4-Benzylidene amino antipyrene (CAS 83-17-0)
- 2-[(3R)-oxolan-3-yl]acetic acid (CAS 146255-25-6)
- Methyl 5,6-difluoronicotinate (CAS 1214336-05-6)
- N-Benzyl-5-(4-fluorophenyl)-1,3,4-oxadiazol-2-amine (CAS 918964-43-9)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
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