Ciprofloxacin Impurity 19 CAS 26832-89-3
| CAS No. | 26832-89-3 |
| Molecular Formula | C14H15Cl2NO4 |
| Molecular Weight | 332.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ciprofloxacin Impurity 19 (CAS 26832-89-3, C14H15Cl2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ciprofloxacin Impurity 19 (C14H15Cl2NO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15Cl2NO4 |
| Molecular Weight | 332.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ciprofloxacin Standards
- Ciprofloxacin (CAS 85721-33-1)
- Ciprofloxacin Impurity 32 (CAS CATO-C4X-136232)
- Ciprofloxacin Impurity 37 (CAS CATO-C4X-136237)
- Ciprofloxacin-d8 (CAS 1130050-35-9)
- Ciprofloxacin Impurity 2 (CAS 528851-85-6)
- Ciprofloxacin Impurity 42 (CAS CATO-C4X-136242)
- Ciprofloxacin Impurity 28 (CAS CATO-C4X-136228)
- Ciprofloxacin Impurity 48 (CAS CATO-C4X-136248)
Recommended Standards
- Hydrochlorothiazide 5-Chloro Impurity (CAS 5233-42-1)
- Alprazolam impurity 21 (CAS 37945-06-5)
- Perfluorophenyl benzo[d][1,3]dioxole-4-carboxylate (CAS 910322-49-5)
- Estazolam Impurity 1 (CAS CATO-C4X-19221)
- Acetaminophen EP Impurity F (CAS 100-02-7)
- Tofacitinib Impurity 144 (CAS 2091669-67-7)
- Benserazide Impurity 18 (CAS 2144-08-3)
- 2-(Benzylthio)quinazolin-4-ol (CAS 6344-77-0)
- 1-(Benzo[d]isothiazol-4-yl)ethan-1-one (CAS 1558215-70-5)
- 4-Acetylbenzenesulfonohydrazide (CAS 890522-64-2)
- 2-(2-Chlorophenyl)cyclopropan-1-amine hydrochloride (CAS 90562-29-1)
- Alverine EP Impurity C HCl (CAS 13125-63-8)
- 2-(3-Ethoxyphenoxy)-4-methylaniline (CAS 946716-66-1)
- D-Thr7-Tirzepatide (CAS CATO-CPTD788924)
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