Alprazolam impurity 21 CAS 37945-06-5
| CAS No. | 37945-06-5 |
| Molecular Formula | C16H11Cl2N3O |
| Molecular Weight | 332.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Alprazolam impurity 21 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Alprazolam impurity 21 (CAS 37945-06-5), a pharmacopoeial impurity reference standard (molecular formula C16H11Cl2N3O, MW 332.18 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Alprazolam impurity 21 (C16H11Cl2N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H11Cl2N3O |
| Molecular Weight | 332.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Alprazolam Standards
- Alprazolam EP Impurity B (CAS 38150-27-5)
- Alprazolam EP Impurity B (CAS CATO-C4X-146014)
- Alprazolam Impurity 8 (CAS 30896-65-2)
- Alprazolam 5,6-Epoxide (CAS 36916-14-0)
- Alprazolam Impurity 9 (CAS 17387-32-5)
- Alprazolam EP Impurity D (CAS CATO-C4X-146010)
- Alprazolam EP Impurity F (CAS 37945-07-6)
- Alprazolam Impurity 16 (CAS CATO-C4X-146016)
Recommended Standards
- Ciprofloxacin Impurity 19 (CAS 26832-89-3)
- Estazolam Impurity 1 (CAS CATO-C4X-19221)
- Hydrochlorothiazide 5-Chloro Impurity (CAS 5233-42-1)
- 6-Chloro-N2-(4-chlorophenyl)-N4-phenyl-1,3,5-triazine-2,4-diamine (CAS 100961-15-7)
- Tazobactam Impurity 8 (CAS CATO-C4X-12058)
- Atorvastatin impurity 157 (CAS 1581251-44-6)
- Rivastigmine Impurity 29 (CAS CATO-C4X-138429)
- (3-Iodo-5-methylphenyl)methanol (CAS 937638-61-4)
- 4-ethyl-4H,5H,6H,7H-[1,2,5]selenadiazolo[3,4-d]pyrimidine-5,7-dione (CAS 2934736-74-8)
- Methyl 4-bromo-3-sulfamoylbenzoate (CAS 74451-73-3)
- 7-Chloro-2-(chloromethyl)pyrido[1,2-a]pyrimidin-4-one (CAS 162469-87-6)
- (6,8-dibromo-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine-3,3-diyl)bis(methylene) bis(2-hexyldecanoate) (CAS 2882848-55-5)
- 2-Chloro-5-sulfobenzoic acid (CAS 40284-70-6)
- C-Peptide 1 (rat) (CAS 41475-27-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com