Estazolam Impurity 1 CAS CATO-C4X-19221
| CAS No. | CATO-C4X-19221 |
| Molecular Formula | C16H11Cl2N3O |
| Molecular Weight | 332.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Estazolam Impurity 1 (CAS CATO-C4X-19221) is a certified pharmaceutical impurity reference standard with the molecular formula C16H11Cl2N3O and a molecular weight of 332.18 g/mol.
Structurally, Estazolam Impurity 1 (C16H11Cl2N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 332.18 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11Cl2N3O |
| Molecular Weight | 332.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Estazolam Standards
Recommended Standards
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- 4,4,5,5,6,6,7,7-octafluoro-1-phenylhept-2-en-1-one (CAS 110960-48-0)
- Indacaterol Impurity 14 (CAS 173140-90-4)
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- Nifedipine Impurity 21 (CAS 80742-13-8)
- 2-Acrylic acid-2-hydroxy-1,3-propanediester (CAS 1709-71-3)
- 3-Ethyl-3-methylpentan-1-ol (CAS 10524-71-7)
- 8-Dechloro-9-chloro Desloratadine (CAS 117811-13-9)
- 6-(5-Bromo-2-methoxyphenyl)picolinaldehyde (CAS 887979-69-3)
- 1-(2,5-Dichlorobenzyl)cyclopropan-1-amine (CAS 1482917-77-0)
- tert-Butyl 7-hydroxy-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate (CAS 167159-80-0)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
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