Buspirone EP Impurity D CAS 2724726-67-2
| CAS No. | 2724726-67-2 |
| Molecular Formula | C24H38N8O |
| Molecular Weight | 454.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Buspirone EP Impurity D (CAS 2724726-67-2, C24H38N8O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Buspirone EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 454.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H38N8O |
| Molecular Weight | 454.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 8 |
Related Buspirone Standards
- Buspirone impurity 32 (CAS CATO-C4X-125832)
- Buspirone impurity 30 (CAS CATO-C4X-125830)
- Buspirone impurity 28 (CAS CATO-C4X-125828)
- Buspirone EP Impurity E (CAS 257877-43-3)
- Buspirone impurity 01 (CAS 105496-33-1)
- Buspirone N-Oxide (CAS 220747-81-9)
- Buspirone impurity 38 (CAS CATO-C4X-125838)
- Buspirone-d8 Hydrochloride (CAS 204395-49-3)
Recommended Standards
- 2-((3-Benzyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)-N-(2-cyano-3-methylbutan-2-yl)acetamide (CAS 744268-04-0)
- 1-Methyl-3,4-dihydroisoquinoline hydrochloride (CAS 26210-39-9)
- Verapamil (CAS 52-53-9)
- 3-((2-(tert-Butyl)-4-hydroxy-5-methylphenyl)thio)-4-hydroxy-6-isopropyl-6-phenethyl-5,6-dihydro-2H-pyran-2-one (CAS 260257-94-1)
- Delafloxacin impurity 38 (CAS 906088-99-1)
- CAS 93692-15-0 (CAS 93692-15-0)
- Ribavirin Impurity 15 (CAS 406680-61-3)
- N'-(5-Ethyl-1H-pyrazol-3-yl)acetimidamide (CAS 742672-37-3)
- 2-((5-Methyl-1,3,4-thiadiazol-2-yl)thio)-1-phenylpropan-1-one (CAS 1088215-62-6)
- 6-Bromo-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one (CAS 1396777-58-4)
- Rel-(3aR,7aS)-octahydrofuro[3,2-c]pyridine hydrochloride (CAS 1629784-77-5)
- tert-Butyl (2-(3-aminopropoxy)ethyl)carbamate (CAS 192132-79-9)
- 5-Bromo-3-(pyrrolidin-1-ylmethyl)-1h-indole (CAS 1108616-48-3)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
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