Verapamil CAS 52-53-9
| CAS No. | 52-53-9 |
| Molecular Formula | C27H38N2O4 |
| Molecular Weight | 454.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Verapamil.
Verapamil (CAS 52-53-9), molecular formula C27H38N2O4 and molecular weight 454.60 g/mol, is a CATO reference standard with documented purity and traceability.
Verapamil (C27H38N2O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H38N2O4 |
| Molecular Weight | 454.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Verapamil Standards
- (R)-(+)-Verapamil HCl (CAS 38321-02-7)
- Verapamil EP Impurity O (CAS 959011-16-6)
- Verapamil EP Impurity H (CAS 67018-83-1)
- (S)-(-)-Verapamil HCl (CAS 36622-29-4)
- Verapamil EP Impurity J (CAS 67018-85-3)
- Verapamil EP Impurity I (CAS 2893-91-6)
- Verapamil Impurity 36 (CAS 77326-93-3)
- Verapamil Impurity 37 (CAS 67018-80-8)
Recommended Standards
- 2-((3-Benzyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)-N-(2-cyano-3-methylbutan-2-yl)acetamide (CAS 744268-04-0)
- Bazedoxifene Acetate Impurity 6 (CAS CATO-C4X-12886)
- Buspirone EP Impurity D (CAS 2724726-67-2)
- Bazedoxifene Acetate Impurity 5 (CAS 389795-08-8)
- tert-Butyl 2-amino-7,8-dihydropyrido[3,2-d]pyrimidine-5(6H)-carboxylate (CAS 1421312-14-2)
- 3-Methyltetrahydro-2H-thiopyran-4-amine (CAS 1314908-85-4)
- N-Benzyl-2,4,5-trichloroaniline (CAS 356530-71-7)
- 9-(2-Chloro-6-fluorobenzyl)-N-methyl-9H-purin-6-amine (CAS 70091-21-3)
- Z-12-Pentacosene (CAS 56927-05-0)
- Boc-Leu-OH-<SUP>15</SUP>N monohydrate (CAS 146953-81-3)
- Methyl 3-aminopentanoate (CAS 147050-41-7)
- Ytterbium(iii)oxalatehexahydrate (CAS 30618-32-7)
- 1,2-Bis(3-(hexyloxy)phenyl)ethane-1,2-dione (CAS 1416047-41-0)
- Liraglutide Impurity 25 (CAS CATO-C4X-199225)
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