Nizatidine EP Impurity H CAS 27366-72-9
| CAS No. | 27366-72-9 |
| Molecular Formula | C4H10N2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nizatidine EP Impurity H is closely related to sulfur-containing functionality, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Nizatidine EP Impurity H (CAS 27366-72-9) is a certified pharmaceutical impurity reference standard with the molecular formula C4H10N2SHCl and a molecular weight of 154.66 g/mol.
The molecular framework of Nizatidine EP Impurity H (C4H10N2SHCl) is characterized by sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H10N2S HCl |
| Molecular Weight | 154.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Nizatidine Standards
- Nizatidine N-Oxide (CAS 102273-12-1)
- Nizatidine EP Impurity C (CAS 102273-13-2)
- Nizatidine EP Impurity K (CAS 112233-23-5)
- Nizatidine EP Impurity F (CAS 1193434-62-6)
- Nizatidine EP Impurity G (CAS 1193434-63-7)
- Nizatidine-d3 (CAS 1246833-99-7)
- Nizatidine EP Impurity E (CAS 188666-11-7)
- Nizatidine EP Impurity H (CAS 27507-28-4)
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