Crisaborole Impurity 52 CAS 2737-22-6
| CAS No. | 2737-22-6 |
| Molecular Formula | C7H3Br3O2 |
| Molecular Weight | 358.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Crisaborole Impurity 52 (CAS 2737-22-6, C7H3Br3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C7H3Br3O2, Crisaborole Impurity 52 contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 358.81 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H3Br3O2 |
| Molecular Weight | 358.81 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole impurity 117 (CAS CATO-C4X-2021117)
- Crisaborole Impurity 26 (CAS CATO-C4X-202126)
- Crisaborole Impurity 136 (CAS CATO-C4X-2021136)
- Crisaborole impurity 131 (CAS 2250222-38-7)
- Crisaborole lmpurity 99 (CAS 2981430-50-4)
- Crisaborole Impurity 61 (CAS CATO-C4X-202161)
- Crisaborole Impurity 37 (CAS CATO-C4X-202137)
- Crisaborole Impurity 27 (CAS 2141947-89-7)
Recommended Standards
- Cl-PEG6-acid (CAS 2365309-92-6)
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- 4-Chloro-2-cyclopentylphenyl-β-D-galactopyranoside (CAS 24718-43-2)
- 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoyl chloride (CAS 162756-62-9)
- Resmetirom impurity 132 (CAS 2542038-65-1)
- Decitabine Impurity 33 (CAS CATO-C4X-113733)
- Bicalutamide Impurity 27 (CAS 937802-59-0)
- (1-((Tetrahydro-2H-pyran-2-yl)methyl)-1H-pyrazol-4-yl)methanamine (CAS 1341734-06-2)
- Aztreonam Impurity 121 (CAS CATO-C4X-1522121)
- 1-(3-Chlorophenyl)-1,2-propanedione 2-Oxime (CAS 56472-71-0)
- 1-Benzoyl-1H-indazol-5-yl benzoate (CAS 36174-08-0)
- Pinacolone oxime (CAS 2475-93-6)
- 2,2'-(1,2-Diaminoethane-1,2-diyl)diphenol (CAS 51208-45-8)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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