Crisaborole impurity 117 CAS CATO-C4X-2021117
| CAS No. | CATO-C4X-2021117 |
| Molecular Formula | C16H14BrNO4 |
| Molecular Weight | 364.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crisaborole impurity 117 (CAS CATO-C4X-2021117) is a certified pharmaceutical impurity reference standard with the molecular formula C16H14BrNO4 and a molecular weight of 364.19 g/mol.
The molecular framework of Crisaborole impurity 117 (C16H14BrNO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Crisaborole impurity 117 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H14BrNO4 |
| Molecular Weight | 364.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 136 (CAS CATO-C4X-2021136)
- Crisaborole lmpurity 99 (CAS 2981430-50-4)
- Crisaborole Impurity 52 (CAS 2737-22-6)
- Crisaborole impurity 162 (CAS CATO-C4X-2021162)
- Crisaborole Impurity 147 (CAS CATO-C4X-202147)
- Crisaborole Impurity 103 (CAS CATO-C4X-2021103)
- Crisaborole Impurity 26 (CAS CATO-C4X-202126)
- Crisaborole impurity 131 (CAS 2250222-38-7)
Recommended Standards
- 477848-07-0 KS-00001R4Y methyl 4-{[(E)-(3-bromo-2-hydroxy-5-methoxyphenyl)methylidene]amino}benzenecarboxylate (CAS 477848-07-0)
- tert-Butyl 5-nitro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate (CAS 1186638-24-3)
- N1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N2-(4-chlorobenzyl)ethane-1,2-diamine (CAS 338406-37-4)
- tert-Butyl (2-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate (CAS 1404561-06-3)
- Gefitinib Impurity 54 (CAS 675126-26-8)
- Semaglutide Impurity 123 (CAS 71997-93-8)
- Tryptophan EP Impurity G (CAS 21704-80-3)
- 4-(1H-Imidazol-2-yl)benzene-1,2-diamine (CAS 261778-64-7)
- N-Acetyl-4-(chloromethyl)-L-phenylalanine Ethyl Ester (CAS 130887-73-9)
- cis-3-(Boc-amino)-4-methoxypyrrolidine (CAS 128739-89-9)
- 2-(5,6-Dibromo-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)acetic acid (CAS 380428-86-4)
- tert-Butyl(2,3-difluorophenoxy)dimethylsilane (CAS 870646-82-5)
- Ethyl 5-benzyl-5-azaspiro[2.4]heptane-7-carboxylate (CAS 351369-91-0)
- Semaglutide Impurity 125 xTFA Salt (CAS CATO-C4X-2226125)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com