Abrocitinib Impurity 25 CAS 2744171-52-4
| CAS No. | 2744171-52-4 |
| Molecular Formula | C14H21N5O3S |
| Molecular Weight | 339.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Abrocitinib Impurity 25.
Abrocitinib Impurity 25 (CAS 2744171-52-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H21N5O3S and a molecular weight of 339.40 g/mol.
The molecular framework of Abrocitinib Impurity 25 (C14H21N5O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H21N5O3S |
| Molecular Weight | 339.40 g/mol |
| Purity | 98% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Abrocitinib Standards
- Abrocitinib Impurity 26 (CAS 2744171-53-5)
- Abrocitinib Impurity 1 (CAS CATO-C4X-28841)
- Abrocitinib Impurity 2 (CAS CATO-C4X-28842)
- Abrocitinib Impurity 20 (CAS CATO-C4X-288420)
- Abrocitinib Impurity 32 (CAS CATO-C4X-288432)
- Abrocitinib Impurity 50 (CAS CATO-C4X-288450)
- Abrocitinib Impurity 41 (CAS 2504210-45-9)
- Abrocitinib Impurity 12 (CAS CATO-C4X-288412)
Recommended Standards
- tert-Butyl(2R,4R)-2-((benzyloxy)methyl)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate (CAS 2757097-05-3)
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- 7-(Morpholine-4-sulfonyl)-3-(propan-2-yl)-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 1007999-27-0)
- rel-tert-Butyl (2R,4R)-2-((benzyloxy)methyl)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate (CAS 2763156-90-5)
- Neratinib Impurity 62 (CAS CATO-C4X-113462)
- Erlotinib Impurity 57 (CAS 1312937-41-9)
- Nicardipine Impurity 61 (CAS CATO-C4X-171061)
- tert-Butyldimethyl(4-vinylphenoxy)silane (CAS 84494-81-5)
- N-(6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-2-yl)acetamide (CAS 1187968-47-3)
- (1R,2R)-2-fluoro-2-methylcyclohexan-1-ol (CAS 120400-90-0)
- rac 11-cis-3-Hydroxy Retinal (CAS 102918-00-3)
- [(1s,9ar)-octahydro-1h-quinolizin-1-yl]methanamine dihydrochloride (CAS 23495-72-9)
- (S)-1-(3-bromo-4-fluorophenyl)but-3-en-1-amine (CAS 1270157-18-0)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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