Varenicline Impurity N22 CAS 2759288-58-7
| CAS No. | 2759288-58-7 |
| Molecular Formula | C14H12F3N3O |
| Molecular Weight | 295.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 295.26 g/mol gives Varenicline Impurity N22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Varenicline Impurity N22 (CAS 2759288-58-7) is a certified pharmaceutical impurity reference standard with the molecular formula C14H12F3N3O and a molecular weight of 295.26 g/mol.
Varenicline Impurity N22 (C14H12F3N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Varenicline Impurity N22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12F3N3O |
| Molecular Weight | 295.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Varenicline Standards
- Varenicline Impurity 52 (CAS CATO-C4X-196252)
- Varenicline Impurity 1 (CAS 230615-53-9)
- Varenicline Impurity 19 (CAS 230615-69-7)
- Varenicline Impurity 34 (CAS CATO-C4X-196234)
- Varenicline Impurity 47 (CAS CATO-C4X-196247)
- Varenicline Impurity 18 (CAS 230615-70-0)
- Varenicline Impurity 55 (CAS CATO-C4X-196255)
- Varenicline Impurity 40 (CAS CATO-C4X-196240)
Recommended Standards
- Afoxolaner impurity 3 (CAS CATO-C4X-31373)
- 3-(4-Fluorophenyl)-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazol-3-yl]acrylonitrile (CAS 1164552-43-5)
- (2s,4r)-1-(Diisopropoxyphosphoryl)-4-hydroxypyrrolidine-2-carboxylic acid (CAS 117286-92-7)
- N-benzyl-2-methyl-4-(trifluoromethyl)pyrimidine-5-carboxamide (CAS 866137-66-8)
- Baloxavir Impurity 29 (CAS 1985607-83-7)
- Baricitinib Impurity 39 (CAS 1146629-76-6)
- Cefprozil Impurity 37 (CAS CATO-C4X-149237)
- tert-Butyl (2-((2-(4-chlorophenyl)-1-iodopropan-2-yl)oxy)ethyl)carbamate (CAS 271245-28-4)
- 1-(3-Amino-5-chloropyridin-4-yl)ethan-1-one (CAS 1393574-79-2)
- 1-Methyl-1h-pyrazole-3,4-dicarboxylic acid (CAS 10505-21-2)
- 5-Chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine (CAS 1256803-09-4)
- Ethyl 5-acetyl-2-amino-4,5,6,7-tetrahydrothieno-[3,2-c]pyridine-3-carboxylate (CAS 924829-09-4)
- 2-(2-Chlorophenyl)-4-(4-methylbenzylidene)oxazol-5(4H)-one (CAS 89242-30-8)
- Glucagon Monohydrochloride (CAS 28270-04-4)
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