Varenicline Impurity 1 CAS 230615-53-9
| CAS No. | 230615-53-9 |
| Molecular Formula | C13H11F3N2O3 |
| Molecular Weight | 300.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Varenicline Impurity 1 (CAS 230615-53-9), a pharmacopoeial impurity reference standard (molecular formula C13H11F3N2O3, MW 300.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Varenicline Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 300.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Varenicline Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11F3N2O3 |
| Molecular Weight | 300.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2022 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Varenicline Standards
- Varenicline Impurity 52 (CAS CATO-C4X-196252)
- Varenicline Impurity N22 (CAS 2759288-58-7)
- Varenicline Impurity 18 (CAS 230615-70-0)
- Varenicline Impurity 55 (CAS CATO-C4X-196255)
- Varenicline Impurity 35 (CAS CATO-C4X-196235)
- Varenicline Impurity 19 (CAS 230615-69-7)
- Varenicline Impurity 34 (CAS CATO-C4X-196234)
- Varenicline Impurity 47 (CAS CATO-C4X-196247)
Recommended Standards
- Tadalafil Impurity 78 (CAS CATO-C4X-108778)
- H-Ala-AFC trifluoroacetate salt (CAS 126910-31-4)
- Memantine Impurity 63 (CAS 875211-09-9)
- N,N-Dimethyl-5-oxo-1-(3-(trifluoromethyl)phenyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000574-18-4)
- Ribociclib Impurity 34 (CAS CATO-C4X-310034)
- (Z)-Ceftazidime Impurity 36 (CAS CATO-C4X-121236)
- Lornoxicam Impurity 79 (CAS 1629463-16-6)
- 2-(4-Iodo-5-methyl-1H-pyrazol-1-yl)acetonitrile (CAS 1823843-24-8)
- 3-(6-Nitro-4-oxo-3,4-dihydroquinazolin-3-yl)propanoic acid (CAS 880457-30-7)
- Trifluoromethanesulfonic anhydride (CAS 358-23-6)
- 2-Amino-3-{[(2-methoxyphenyl)methyl]sulfanyl}propanoic acid (CAS 1485758-89-1)
- 3-Chloro-5-(3-chlorophenyl)-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 691868-55-0)
- pTH (1-34) (rat) (CAS 98614-76-7)
- D-[His]1-Semaglutide (CAS CATO-C4X-222652)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com