Naproxen Impurity 20 CAS 27655-95-4
| CAS No. | 27655-95-4 |
| Molecular Formula | C14H13BrO3 |
| Molecular Weight | 309.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C14H13BrO3, Naproxen Impurity 20 contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 309.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Naproxen Impurity 20 (CAS 27655-95-4, C14H13BrO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Naproxen Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H13BrO3 |
| Molecular Weight | 309.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Br-containing |
Related Naproxen Standards
- Naproxen EP Impurity C (CAS 84236-26-0)
- Naproxen Glycerol Ester Impurity (CAS 38835-17-5)
- Naproxen Impurity 34 (CAS CATO-C4X-170834)
- Naproxen Impurity 35 (CAS CATO-C4X-170835)
- Naproxen Impurity 38 (CAS 2514763-96-1)
- Naproxen Impurity 16 (CAS CATO-C4X-170816)
- Naproxen Impurity 18 (CAS 2601735-81-1)
- Naproxen Impurity 17 (CAS CATO-C4X-170817)
Recommended Standards
- 959578-19-9 Ethyl 5-bromo-1-(4-methylphenyl)-1H-pyrazole-4-carboxylate DTXSID40377228 (CAS 959578-19-9)
- N-(6-Bromo-8-ethyl-2-hydroxyquinolin-5-yl)acetamide (CAS 91761-88-5)
- 4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)benzonitrile (CAS 1205683-41-5)
- n-(4-Bromobenzyl)-n,5-dimethylisoxazole-3-carboxamide (CAS 850025-17-1)
- Vonoprazan Impurity 275 (CAS CATO-C4X-1020275)
- Rebamipide impurity 02 (CAS 1984832-92-9)
- Azithromycin Impurity 40 (CAS 76820-32-1)
- Cefodizime Impurity 16 (CAS CATO-C4X-180616)
- 3-(2-hydroxyethyl)furan-2-carboxylic acid (CAS 55832-62-7)
- Methyl({[1-(pyridin-4-yl)piperidin-4-yl]methyl})amine (CAS 392330-25-5)
- 1-(4-Ethoxyphenyl)cyclobutan-1-amine (CAS 1094442-38-2)
- tert-Butyl 2-(2-methoxyphenyl)piperidine-1-carboxylate (CAS 1355200-52-0)
- Ethyl 3-(3-chlorophenyl)-1,2,4-oxadiazole-5-carboxylate (CAS 478030-49-8)
- Des-[Oct-γ-Glu-AEEA-AEEA]-Semaglutide (CAS CATO-C4X-2226112)
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