7-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol CAS 2773311-37-6
| CAS No. | 2773311-37-6 |
| Molecular Formula | C16H18BFO3 |
| Molecular Weight | 288.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol.
7-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol (CAS 2773311-37-6) is a high-purity analytical reference standard with the molecular formula C16H18BFO3 and a molecular weight of 288.12 g/mol.
The molecular framework of 7-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol (C16H18BFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18BFO3 |
| Molecular Weight | 288.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 1-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol (CAS 2638502-42-6)
- 6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol (CAS 2667057-65-8)
- 6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-amine (CAS 1257378-82-7)
- 1-Fluoro-3-(4-iodophenyl)bicyclo[1.1.1]Pentane (CAS 1934526-34-7)
- 1-(3-Fluoro-benzyl)-piperidine-3-carboxylic acid (CAS 1042911-09-0)
- 7-Fluoro-6-iodoisoquinolin-3-amine (CAS 2409844-29-5)
- 4-Fluoro-5-Oxo-2,4-Bis(Trifluoromethyl)-1,3-Dioxolane-2-Carbonyl Fluoride (CAS 7345-49-5)
- 4-(2-Fluoro-4-nitrophenoxy)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (CAS 875339-19-8)
Recommended Standards
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- Benzo[1,2-c:3,4-c’:5,6-c’’]trifuran-1,3,4,6,7,9-hexaone (CAS 4253-24-1)
- 6-Iodo-1,1,5-trimethyl-1,3-dihydroisobenzofuran (CAS 2886002-32-8)
- Methyl 4-bromo-7-oxo-6,7-dihydrothieno[2,3-c]pyridine-2-carboxylate (CAS 870243-95-1)
- n-((4-Bromothiophen-3-yl)methyl)-2-methoxyethan-1-amine (CAS 1522933-48-7)
- 4-(3,5-Dichloro-4-methylphenyl)-4-oxobutanoic acid (CAS 62903-05-3)
- 2-(tert-Butyl)quinolin-8-ol (CAS 71104-54-6)
- 3-Fluoro-5-(isopentyloxy)-4-methylbenzoic acid (CAS 1429901-77-8)
- 2-Methyl-5-(4h-1,2,4-triazol-4-yl)phenol (CAS 1343629-28-6)
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- 7-Cyano-1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid (CAS 1190318-42-3)
- 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-ol (CAS 1226194-06-4)
- N1,N1,N3-trimethyl-N3-(piperidin-4-yl)propane-1,3-diamine (CAS 1067660-91-6)
- Peptide Impurity 24 (CAS CATO-CPTD788824)
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