Vonoprazan Impurity 212 CAS 2775441-80-8
| CAS No. | 2775441-80-8 |
| Molecular Formula | C21H16FN3O5S2 |
| Molecular Weight | 473.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Vonoprazan Impurity 212 (C21H16FN3O5S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Vonoprazan Impurity 212 (CAS 2775441-80-8, C21H16FN3O5S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H16FN3O5S2 |
| Molecular Weight | 473.50 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Vonoprazan Standards
- Vonoprazan Impurity 162 (CAS CATO-C4X-1020162)
- Vonoprazan Impurity 193(Mixture of Z and E Isomers) (CAS CATO-C4X-1020193)
- Vonoprazan Impurity 199 (CAS CATO-C4X-1020199)
- Vonoprazan Impurity 66 (CAS 2170020-79-6)
- Vonoprazan Impurity 125 (CAS CATO-C4X-1020125)
- Vonoprazan Impurity 213 (CAS CATO-C4X-1020213)
- Vonoprazan Impurity 145 (CAS CATO-C4X-1020145)
- Vonoprazan Impurity 238 (CAS 1831110-76-9)
Recommended Standards
- Rosuvastatin Intermediates (CAS 937639-31-1)
- MK-2894, >98% (HPLC) (CAS 1006036-87-8)
- Rosiglitazone N-(2-Succinic Acid) (CAS 956239-35-3)
- n-(4-(1h-Imidazol-1-yl)phenyl)-4-(n-(4-(1h-imidazol-1-yl)phenyl)sulfamoyl)-1h-pyrrole-2-carboxamide (CAS 1031121-18-2)
- Estradiol Valerate EP Impurity C (CAS 95959-20-9)
- Formoterol Impurity 62 (CAS CATO-C4X-152562)
- Dienogest Impurity 15 (CAS CATO-C4X-229515)
- [(Anthracen-9-yl)methyl](butan-2-yl)amine (CAS 444576-97-0)
- Trimethyllead Chloride (CAS 1520-78-1)
- Thieno[2,3-b]quinoline-2-carboxylic acid (CAS 52026-70-7)
- 1-(4-Methoxyphenyl)-2-{[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-1-ethanone (CAS 332884-42-1)
- 4-(Chloromethyl)-4-ethyl-2-methylhexane (CAS 1497180-84-3)
- 9-Benzyl-2-chloro-N-(4-fluorophenyl)-9H-purin-6-amine hydrochloride (CAS 125802-52-0)
- Neuroendocrine Regulatory Peptide-1 (human) (H-6622.1000) (CAS 954420-50-9)
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