Vonoprazan Impurity 145 CAS CATO-C4X-1020145
| CAS No. | CATO-C4X-1020145 |
| Molecular Formula | C20H18FN3O6S |
| Molecular Weight | 447.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Vonoprazan Impurity 145 (CAS CATO-C4X-1020145, C20H18FN3O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Vonoprazan Impurity 145 (C20H18FN3O6S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Vonoprazan Impurity 145 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H18FN3O6S |
| Molecular Weight | 447.44 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impurity 238 (CAS 1831110-76-9)
- Vonoprazan Impurity 174 (CAS CATO-C4X-1020174)
- Vonoprazan Impurity 185 (CAS CATO-C4X-1020185)
- Vonoprazan Fumarate Impurity 122 (CAS CATO-C4X-1020122)
- Vonoprazan Impurity 66 (CAS 2170020-79-6)
- Vonoprazan Impurity 253 (CAS CATO-C4X-1020253)
- Vonoprazan Impurity 162 (CAS CATO-C4X-1020162)
- Vonoprazan Impurity 296 (CAS CATO-C4X-1020296)
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