Amlodipine Impurity 64 CAS 27807-84-7
| CAS No. | 27807-84-7 |
| Molecular Formula | C4H5ClO3 |
| Molecular Weight | 136.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Amlodipine Impurity 64 (CAS 27807-84-7) is a certified pharmaceutical impurity reference standard with the molecular formula C4H5ClO3 and a molecular weight of 136.53 g/mol.
The molecular framework of Amlodipine Impurity 64 (C4H5ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Amlodipine Impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H5ClO3 |
| Molecular Weight | 136.53 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
Related Amlodipine Standards
- Amlodipine Impurity 65 (CAS 89-98-5)
- Amlodipine Impurity N17 (CAS 21759-69-3)
- Amlodipine Impurity 91 (CAS 1465559-94-7)
- Amlodipine Impurity 54 (CAS 136744-85-9)
- Amlodipine Impurity N18 (CAS 72569-97-2)
- Amlodipine Impurity 28 (CAS 21731-17-9)
- Amlodipine Impurity 39 (CAS 5183-78-8)
- Amlodipine Impurity 89 (CAS CATO-C4X-109589)
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