Amlodipine Impurity 65 CAS 89-98-5
| CAS No. | 89-98-5 |
| Molecular Formula | C7H5ClO |
| Molecular Weight | 140.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 140.57 g/mol gives Amlodipine Impurity 65 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Amlodipine Impurity 65 (CAS 89-98-5, C7H5ClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Amlodipine Impurity 65 (C7H5ClO) is characterized by a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClO |
| Molecular Weight | 140.57 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Amlodipine Standards
- Amlodipine Impurity 64 (CAS 27807-84-7)
- Amlodipine Impurity N17 (CAS 21759-69-3)
- Amlodipine Impurity 54 (CAS 136744-85-9)
- Amlodipine Impurity N18 (CAS 72569-97-2)
- Amlodipine Impurity 91 (CAS 1465559-94-7)
- Amlodipine Impurity 28 (CAS 21731-17-9)
- Amlodipine Impurity 39 (CAS 5183-78-8)
- Amlodipine Impurity 89 (CAS CATO-C4X-109589)
Recommended Standards
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- Drotaverine Impurity 19 (CAS CATO-C4X-243519)
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