Apixaban Impurity 104 CAS 5819-34-1
| CAS No. | 5819-34-1 |
| Molecular Formula | C4H5ClO3 |
| Molecular Weight | 136.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Apixaban Impurity 104 (C4H5ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 136.53 g/mol, it falls into the low-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Apixaban Impurity 104 (CAS 5819-34-1, C4H5ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Apixaban Impurity 104 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H5ClO3 |
| Molecular Weight | 136.53 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Apixaban Standards
- Apixaban Impurity 21 (CAS 1119-46-6)
- Apixaban Impurity 96 (CAS 3471-32-7)
- Apixaban Impurity 92 (CAS 2403-63-6)
- Apixaban Impurity 111 (CAS 104-94-9)
- Apixaban Impurity 182 (CAS CATO-C4X-1088182)
- Apixaban Impurity 85 (CAS 14273-86-0)
- Apixaban Impurity 38 (CAS CATO-C4X-108838)
- Apixaban Impurity 67 (CAS 2323-81-1)
Recommended Standards
- (Chloroformyl)acetic Acid Methyl Ester 3-Chloro-3-oxopropionic Acid Methyl Ester 37517-81-0 M2315 Methyl (Chloroformyl)acetate Methyl 3-Chloro-3-oxopropionate Methyl Malonyl Chloride (CAS 37517-81-0)
- Amlodipine Impurity 64 (CAS 27807-84-7)
- Methyl 3-chloro-2-oxopropanoate (CAS 922-19-0)
- Acetoxyacetyl Chloride (CAS 13831-31-7)
- Nintedanib Impurity 96 (CAS CATO-C4X-181496)
- Apalutamide impurity 91 (CAS CATO-C4X-274991)
- Lifitegrast Impurity 89 (CAS CATO-C4X-240989)
- N-(2-(1H-Imidazo[1,2-b]pyrazol-1-yl)ethyl)-2-bromobenzamide (CAS 1796965-53-1)
- 3-chloro-4-(pyridin-3-ylmethoxy)aniline (CAS 848134-24-7)
- 4-Fluoro-3-methoxy-5-(methylthio)benzaldehyde (CAS 2090518-69-5)
- Cinacalcet impurity 87 (CAS CATO-C4X-105987)
- 5-Ethynyl-1-methylpyridin-2(1H)-one (CAS 1693759-63-5)
- 2-Bromo-3-methyl-5-(piperazin-1-yl)pyrazine (CAS 1260663-09-9)
- Des-Phe22-Tirzepatide (CAS CATO-CPTD788951)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com