Glutathione EP Impurity D TFA Salt CAS 283159-88-6
| CAS No. | 283159-88-6 |
| Molecular Formula | C8H14N2O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Glutathione EP Impurity D TFA Salt.
CATO supplies Glutathione EP Impurity D TFA Salt (CAS 283159-88-6), a pharmacopoeial impurity reference standard (molecular formula C8H14N2O5SC2HF3O2, MW 364.29 g/mol) used for the identification and quantification of trace impurities in APIs.
Glutathione EP Impurity D TFA Salt (C8H14N2O5SC2HF3O2) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H14N2O5S C2HF3O2 |
| Molecular Weight | 364.29 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Glutathione Standards
- Glutathione (CAS 1432061-73-6)
- Glutathione Dimethyl Ester Disulfide DiHCl (CAS 146963-33-9)
- Glutathione Impurity N5 (CAS 17297-99-3)
- Glutathione EP Impurity A (CAS 19246-18-5)
- Glutathione EP Impurity A (CAS 2601-47-0)
- L-Glutathione Oxidized (CAS 27025-41-8)
- Glutathione (1S, 2R)-Isomer (CAS 274260-05-8)
- Glutathione Sodium Salt (CAS 34212-83-4)
Recommended Standards
- Buspirone EP Impurity J Oxalate (CAS 2726492-73-3)
- Sulfadoxine Impurity 12 (CAS CATO-C4X-279112)
- Dotinurad Impurity 225 (CAS CATO-C4X-2494225)
- 6-Amino-4,4-dimethylhexanoic acid hydrochloride (CAS 1354949-80-6)
- tert-Butyl 5-hydroxy-2,9-diazaspiro[5.5]undecane-9-carboxylate (CAS 1367935-91-8)
- Methyl 3-bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine-6-carboxylate (CAS 866133-13-3)
- 5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran (CAS 78027-51-7)
- 3-Difluoromethoxy-2-(trifluoromethyl)benzonitrile (CAS 1806277-11-1)
- 4,5-Dichloropyrimidin-2-ol (CAS 857413-11-7)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com