1,1'-(Methylenebis(2-hydroxy-5,1-phenylene))diethanone CAS 28467-22-3
| CAS No. | 28467-22-3 |
| Molecular Formula | C17H16O4 |
| Molecular Weight | 284.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1,1'-(Methylenebis(2-hydroxy-5,1-phenylene))diethanone.
1,1'-(Methylenebis(2-hydroxy-5,1-phenylene))diethanone (CAS 28467-22-3) is a high-purity analytical reference standard with the molecular formula C17H16O4 and a molecular weight of 284.31 g/mol.
The molecular framework of 1,1'-(Methylenebis(2-hydroxy-5,1-phenylene))diethanone (C17H16O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16O4 |
| Molecular Weight | 284.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
Related Methylenebis Standards
- 2,2'-((Methylenebis(oxy))bis(methylene))bis(2-(hydroxymethyl)propane-1,3-diol) (CAS 6228-26-8)
- 4,4'-Methylenebis(2-ethyl-3-methylaniline) (CAS 1632285-94-9)
- 4,4'-Methylenebis(2-ethyl-6-methylaniline) (CAS 19900-72-2)
- 5,5'-Methylenebis(2-aminobenzoic acid) (CAS 7330-46-3)
- Methylenebis[dimethyl(2-pyridyl)silane] (CAS 243468-48-6)
- 4,4'-Methylenebis[2-chlorophenol] (CAS 2787-77-1)
- 3,3'-Methylenebis(2-hydroxybenzoic acid) (CAS 5578-67-6)
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Recommended Standards
- 1-(5-Nitropyridin-2-yl)-4-phenylpiperazine (CAS 400088-76-8)
- 1,2,4,5-Tetrachloro-3-fluorobenzene (CAS 319-97-1)
- 1-(3-Nitropyridin-2-yl)-4-phenylpiperazine (CAS 73291-11-9)
- 1,2-Cyclohexanedicarboxylic acid, 1,2-bis(2-oxiranylmethyl) ester, homopolymer (CAS 27103-66-8)
- (4-Fluorophenyl)(1-methyl-4-(p-tolyl)pyrrolidin-3-yl)methanone (CAS 338750-26-8)
- 4-(2-Bromobenzyl)thiomorpholine (CAS 414887-06-2)
- 2-((Trimethylsilyl)methyl)benzyl acetate (CAS 100642-59-9)
- 2-(2-Methoxyphenyl)-2,3-dihydroquinolin-4(1H)-one (CAS 204841-40-7)
- 3-(6-Aminobenzo[d]thiazol-2-yl)phenol (CAS 518341-95-2)
- Pentanedioic acid, polymer with N1-(2-aminoethyl)-1,2-ethanediamine (CAS 57604-92-9)
- tert-butyl 4-oxazol-5-ylazepane-1-carboxylate (CAS 2386063-75-6)
- 1-chloro-4-(1-methyl-1H-pyrrol-3-yl)phthalazine (CAS 597552-88-0)
- 1H-Pyrrole-2,4-dicarboxylic acid (CAS 937-26-8)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
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