Edoxaban Impurity 59 (p-Toluenesulfonic acid) CAS 2852734-45-1
| CAS No. | 2852734-45-1 |
| Molecular Formula | C24H30ClN7O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Edoxaban Impurity 59 (p-Toluenesulfonic acid) (CAS 2852734-45-1, C24H30ClN7O4SC7H8O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Edoxaban Impurity 59 (p-Toluenesulfonic acid) is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 720.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Edoxaban Impurity 59 (p-Toluenesulfonic acid) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H30ClN7O4S C7H8O3S |
| Molecular Weight | 720.26 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 2 |
Related Edoxaban Standards
- Edoxaban Impurity 73 (CAS 1057651-37-2)
- Edoxaban Impurity 7 (CAS 1072-98-6)
- Edoxaban Impurity 71 (CAS 1093351-29-1)
- Edoxaban Impurity N8 HCl (CAS 1190971-73-3)
- Edoxaban Impurity 47 (CAS 1210348-16-5)
- Edoxaban Impurity 74 (CAS 1210348-21-2)
- Edoxaban Impurity 20 (CAS 1210348-34-7)
- Edoxaban Tosylate Monohydrate (CAS 1229194-11-9)
Recommended Standards
- Cenobamate impurity 12 (CAS 913088-45-6)
- Roxadustat Impurity 67 (CAS CATO-C4X-221367)
- Estradiol Impurity 23 (CAS 1093411-48-3)
- (5Z)-2-(Methylsulfanyl)-5-{[2-(trifluoromethyl)phenyl]methylidene}-4,5-dihydro-1,3-thiazol-4-one (CAS 860651-28-1)
- 5-Chloro-2-(pyridin-3-yl)indoline (CAS 593234-54-9)
- (S)-2-Amino-N-(2,4-dichlorobenzyl)-N-ethylpropanamide (CAS 1353995-28-4)
- 4-(Bromomethyl)-3-(difluoromethyl)benzonitrile (CAS 1261566-79-3)
- 3-Bromo-5-(pyridin-2-yl)-1,2,4-oxadiazole (CAS 1447958-32-8)
- 2-(4-Amino-3-oxobutyl)-1H-isoindole-1,3(2H)-dione hydrochloride (CAS 3330-06-1)
- Des-Ala35-Tirzepatide (CAS CATO-CPTD788939)
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